6250-76-6

Upstream product

• 5616-32-0 (methylamino)acetonitrile 
• 683-57-8 bromo-acetic acid amide 
• 74-89-5 methylamine 
• 36231-19-3 N-phenylmethoxycarbonylsarcosinamide 
• 79-07-2 Chloroacetamide 
• 81965-43-7 Sarmustine 

Downstream Products

• 106231-62-3 Benzoic acid (carbamoylmethyl-methyl-carbamoyl)-methyl ester 
• 38507-49-2 3-benzyl-1,6-dimethyl-2,4-pyrimidinedione 
• 946129-47-1 N-methyl-N-carbamoylmethylcarbamic acid 4-methyl-3-(3-(methylaminosulfonyl)aminobenzyl)-2-oxo-2H-1-benzopyran-7-yl ester 
• 1250854-66-0 N-(2-amino-2-oxoethyl)-4-iodo-N-methylbenzamide 
• 1258599-96-0 C₁₄H₁₄N₄O₄ 

Relevant academic research and scientific papers

CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY AND PROCESSES FOR THEIR PREPARATION

The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administ

2-Substituted Penems with Amino Acid-Related Side Chains: Synthesis and Antibacterial Activity of a New Series of β-Lactam Antibiotics

A new series of 6-(hydroxyethyl)penems 2-substituted with amino acid-related side chains was synthesized.The nature of the amino acyl derivative proved to be crucial both from a synthetic point of view, as β-lactam ring opening can compete with C-2 nucleophilic substitution, and for antibacterial activity.Primary amino acid amides emerged as the most suitable side chains for enhancing permeability through a Gram-negative outer membrane.In vitro activity of the new 2-penems 3a-u was influenced by the nature and position of the amide moiety, the ring size for cyclic amides, and the configuration of the amino acid.Compounds bearing amides derived from small N-methyl amino acids (such as 3a) or from cyclic amino acids (such as prolinamide 3p and 4-hydroxyprolinamide 3r) showed broad spectrum in vitro activity against both Gram-positive and Gram-negative microorganisms.

Aqueous Solutions Containing Amino Acids and Peptides. Part 19: The Enthalpic Coefficients for the Interactions of N-Acetylsarcosinamide with 2-(N-acetylamino)acyl Amides at 25 deg C

Enthalpies of dilution both of solutions of N-acetylsarcosinamide and of ternary solutions equimolal in N-acetylsarcosinamide and N-acetylglycinamide, N-acetyl-L-alaninamide, N-acetyl-L-valinamide or N-acetyl-L-leucinamide have been determined by a microc