39066-09-6Relevant articles and documents
α-Alkylation of Nitriles with Primary Alcohols by a Well-Defined Molecular Cobalt Catalyst
Paudel, Keshav,Xu, Shi,Ding, Keying
, p. 14980 - 14988 (2020/12/02)
The α-alkylation of nitriles with primary alcohols to selectively synthesize nitriles by a well-defined molecular homogeneous cobalt catalyst is presented. Thirty-two examples with up to 95% yield are reported. Remarkably, this transformation is environmentally friendly and atom economical with water as the only byproduct.
DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS
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Paragraph 000580, (2019/11/04)
The invention provides dihydroisoquinoline-2(1H)-carboxamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as cancer, and in inhibiting HPK1 activity.
Efficient assembly of α-aryl and α-vinyl nitriles via iron-catalyzed ether bond activation
Fan, Xiaohui,Guo, Kun,Guan, Yong-Hong,Fu, Lin-An,Cui, Xiao-Meng,Lv, Hao,Zhu, Hong-Bo
, p. 1068 - 1071 (2014/02/14)
A novel and practical method for the synthesis of diverse α-aryl and α-vinyl nitriles was developed via an iron-catalyzed sp3 C-O ether bond cleavage with C-C bond formation in the reaction of π-activated ethers with TMSCN.