88932-42-7

Upstream product

• 67-56-1 methanol 
• 4180-23-8 E-1-(4'-methoxyphenyl)prop-1-ene 
• 5349-60-0 1-(4-methoxyphenyl)-1-propanol 
• 74-88-4 methyl iodide 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 121-98-2 methyl 4-methoxybenzoate 
• 121-97-1 4-Methoxypropiophenone 
• 39066-09-6 2-(4-methoxy)-phenyl-butyronitrile 
• 104-45-0 4-n-propylanisole 
• 88932-57-4 (3R*,4R*)-3-(2-Nitro-4-methoxyphenyl)-4-(4-methoxyphenyl)hexane 
• 88932-56-3 (3R*,4S*)-3-(2-Nitro-4-methoxyphenyl)-4-(4-methoxyphenyl)hexane 
• 88932-48-3 (3R*,4R*)-3-(2-Nitro-4-methoxyphenyl)-4-(hydroxyphenyl)hexane 
• 88932-47-2 (3R*,4S*)-3-(2-Nitro-4-methoxyphenyl)-4-(hydroxyphenyl)hexane 
• 123-11-5 4-methoxy-benzaldehyde 
• 88932-52-9 (3R*,4S*)-3-(2-Nitro-4-methoxyphenyl)-4-(4-methoxyphenyl)-1-hexene 
• 88932-53-0 (3R*,4R*)-3-(2-Nitro-4-methoxyphenyl)-4-(4-methoxyphenyl)-1-hexene 
• 78387-60-7 (3R*,4S*)-3,4-Bis(4-methoxyphenyl)-1-hexene 
• 88932-44-9 (3R*,4R*)-3,4-Bis(4-methoxyphenyl)-1-hexene 

Relevant academic research and scientific papers

Efficient assembly of α-aryl and α-vinyl nitriles via iron-catalyzed ether bond activation

A novel and practical method for the synthesis of diverse α-aryl and α-vinyl nitriles was developed via an iron-catalyzed sp3 C-O ether bond cleavage with C-C bond formation in the reaction of π-activated ethers with TMSCN.

Efficient assembly of α-aryl and α-vinyl nitriles via iron-catalyzed ether bond activation

A novel and practical method for the synthesis of diverse α-aryl and α-vinyl nitriles was developed via an iron-catalyzed sp3 C-O ether bond cleavage with C-C bond formation in the reaction of π-activated ethers with TMSCN.

Iron-catalyzed N-alkylation using π-activated ethers as electrophiles

A new method for the synthesis of diverse N-alkylation compounds was developed via an iron-catalyzed etheric Csp3-O cleavage with the C-N bond formation in the reaction of π-activated ethers with various nitrogen-based nucleophiles. In addition, the mechanism of this reaction was investigated. The Royal Society of Chemistry 2013.

Controlling factors determining the regiochemistry of intramolecular alkoxymercuration

The intramolecular alkoxymercuration of (E)-5-arylpent-4-en-1-ols indicated that the regioselectivity is closely related to the Hammett constants of the para-substituents on the benzene ring. Large solvent effects on the regioselectivity were also observe

Silicon-Mediated Synthesis of Bibenzyl Systems: Synthesis of Ring and Side-Chain Functionalized Hexestrol Derivatives

Derivatives of hexestrol , a non-steroidal estrogen, bearing photochemically reactive functional groups or γ-emmitting radionuclides, are useful as affinity labeling agents for the estrogen receptor or as imaging agents for receptor positive breast tumors, respectively.We have developed convenient synthetic routes to two side chain functionalized and aromatic ring functionalized hexestrol derivatives, based on a direct benzylic coupling reaction mediated by allylsilanes or silyl ketene acetals. 1-Dehydrohexestrol and variousaromatic ring substituted 1-dehydrohexestrol derivatives can be prepared by coupling 3-(trimethylsilyl)-1-(4-methoxyphenyl)propene with various reactive benzylic derivatives, and pentestrol derivatives are prepared by the coupling of the silyl ketene acetal derivative of p-methoxyphenyl acetic ester with benzylic derivatives.The R*,S* (erythro) and R*,R* (threo) diastereomers formed in each case can be separated readily by chromatography and recrystallization.This silicon-mediated approach to functionalized hexestrol derivatives provides a convenient route to many compounds of interest as biochemical probes and receptor-based diagnostic reagents.