3910-58-5

Usage

InChI:InChI=1/C12H19NO/c1-3-4-9-13-10-11-5-7-12(14-2)8-6-11/h5-8,13H,3-4,9-10H2,1-2H3

Upstream product

• 3910-55-2 N-(p-methoxybenzylidene)butylamine 
• 3910-55-2 N-(4-methoxybenzylidene)-n-butylamine 
• 2746-25-0 p-Methoxybenzyl bromide 
• 109-73-9 N-butylamine 
• 7332-00-5 n-butylazide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 123-11-5 4-methoxy-benzaldehyde 
• 874-90-8 4-methoxybenzonitrile 
• 109-65-9 1-bromo-butane 
• 2393-23-9 4-methoxy-benzylamine 
• 6117-91-5 (E/Z)-2-buten-1-ol 
• 2280-99-1 N-butyl-p-methoxybenzamide 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 24922-69-8 BuNH₂*TFA 
• 123-11-5 4-methoxy-benzaldehyde 
• 2280-99-1 N-butyl-p-methoxybenzamide 
• 1027986-05-5 [(E)-2-(2-Bromo-3,4,5-trimethoxy-phenyl)-1-(4-methoxy-phenyl)-vinyl]-butyl-(4-methoxy-benzyl)-amine 
• 367943-59-7 [[butyl-(4-methoxy-benzyl)-amino]-(4-methoxy-phenyl)-methyl]-phosphonic acid dimethyl ester 

Relevant academic research and scientific papers

Polyoxometalate-Driven Ease Conversion of Valuable Furfural to trans- N, N-4,5-Diaminocyclopenten-2-ones

We investigated the catalytic efficacy of silicotungstic acid (H4SiW12O40) polyoxometalate (POM) toward the reaction between furfural and amines that selectively yields trans-N,N-4,5-substituted-diaminocyclopenten-2-ones (trans-DACPs). H4SiW12O40 facilita

Rhodium catalysts with cofactor mimics for the biomimetic reduction of CN bonds

A strategy based on the cooperation between metal and bonded cofactor mimics was applied to the transfer hydrogenation of CN bonds. We designed and synthesized a rhodium complex containing a 1,3-dimethylbenzoimidazole moiety, which could transfer hydride from a rhodium center to imine substrates in a biomimetic way. Under both transfer hydrogenation and reductive amination reaction conditions, the catalyst exhibited good selectivity towards CN bonds. With the catalyst, 34 imines were transfer hydrogenated to corresponding amines and a key intermediate of retigabine was prepared via reductive amination in a greener way. According to the NMR observations and isotope experiments, a plausible mechanism for this biomimetic reduction of CN bonds were proposed.

Intramolecular C?H Amination of N-Alkylsulfamides by tert-Butyl Hypoiodite or N-Iodosuccinimide

1,3-Diamines are an important class of compounds that are broadly found in natural products and are also widely used as building blocks in organic synthesis. Although the intramolecular C?H amination of N-alkylsulfamide derivatives is a reliable method for the construction of 1,3-diamine structures, the majority of these methods involve the use of a transition-metal catalyst. We herein report on a new transition-metal-free method using tert-butyl hypoiodite (t-BuOI) or N-iodosuccinimide (NIS), enabling secondary non-benzylic and tertiary C?H amination reactions to proceed. The cyclic sulfamide products can be easily transformed into 1,3-diamines. Mechanistic investigations revealed that amination reactions using t-BuOI or NIS each proceed via different pathways.

Switching the N-Alkylation of Arylamines with Benzyl Alcohols to Imine Formation Enables the One-Pot Synthesis of Enantioenriched α-N-Alkylaminophosphonates

The selective N-alkylation of anilines with benzylic alcohols can be switched in favor of the dehydrogenative condensation process using the nitrile-ligated Kn?lker's complex by conducting the reaction either in a closed system under inert conditions, or in an open system in air. The selective formation of imines, containing reactive C=N bonds, provides an opportunity towards further functionalization. Indeed, a one-pot three-component condensation of alcohols, amines and phosphites, promoted by an iron-based Kn?lker-type complex in combination with a chiral BINOL-based phosphoric acid, provides access to enantioenriched α-N-alkylaminophosphonates.

Photocatalyzed cascade Meerwein addition/cyclization of: N -benzylacrylamides toward azaspirocycles

A visible-light-induced cascade Meerwein addition/cyclization of alkenes involving C-F bond cleavage was developed. This method offers a rapid access to azaspirocyclic cyclohexadienones from N-benzylacrylamides via C-F bond cleavage applying H2O as an external oxygen source, allowing for the incorporation of various aromatic moieties originating from aryldiazonium salts.

Reduction of selenoamides to amines using SmI2-H2O

Selenoamides are selectively reduced to amines by SmI2 with H2O. The process is general for primary, secondary, and tertiary aryl and alkyl selenoamide substrates and selectively delivers amine products. The reduction proceeds under mild conditions using SmI2 activated by straightforward addition of H2O, and does not require an additional Lewis base additive.

Visible light-induced intramolecular dearomative cyclization of α-bromo-N-benzyl-alkylamides: Efficient construction of 2-azaspiro[4.5]decanes

An efficient intramolecular dearomative cyclization via visible light-induced photoredox catalysis allows for a highly regioselective dearomative cyclization of α-bromo-N-benzyl-alkylamides to construct 2-azaspiro[4.5]decanes in the presence of an iridium catalyst.

Cs2CO3-Promoted Direct N-Alkylation: Highly Chemoselective Synthesis of N-Alkylated Benzylamines and Anilines

Herein is described an efficient and chemoselective method for the synthesis of diversely substituted secondary amines in yields up to 98 %. Direct mono-N-alkylation of primary benzylamines and anilines with a wide range of alkyl halides is promoted by a cesium base in the absence of any additive or catalyst. The basicity and solubility of cesium carbonate in anhydrous N,N-dimethylformamide not only enables mono-N-alkylation of primary amines but also suppresses undesired dialkylation of the desired amines.

Copper-catalysed reductive amination of nitriles and organic-group reductions using dimethylamine borane

A heterogeneous copper catalyst, formed in situ, has been shown to dehydrocouple commercially available amine boranes whilst transferring hydrogen for the reduction of selected organic functional groups in an aqueous medium. The catalytic system has also been shown to promote the reductive amination of aryl nitriles. This journal is

[2]Pseudorotaxanes based on naphtho-21-crown-7 and secondary dialkylammonium salts: Remarkably improved association constants among four threaded structures

This research article is focused on the recognition interaction of a new host naphtho-21-crown-7 and four secondary dialkylammonium salts. In acetone, they can form 1:1 host-guest complexes which belong to slow-exchange systems. We also found the differen