2280-99-1

Basic information

• Product Name: Benzamide, N-butyl-4-methoxy-
• CAS NO: 2280-99-1
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• Mol File: 2280-99-1.mol
• Article Data: 47

Chemical Properties

• CAS DataBase Reference: Benzamide, N-butyl-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-butyl-4-methoxy-(2280-99-1)
• EPA Substance Registry System: Benzamide, N-butyl-4-methoxy-(2280-99-1)

Safety Data

• Hazardous Substances Data: 2280-99-1(Hazardous Substances Data)

Upstream product

• 15866-24-7 bis-(3,5-dinitro-benzoyl)-peroxide 
• 19920-04-8 tetrakis-(4-methoxy-phenyl)-ethanone 
• 109-73-9 N-butylamine 
• 105-13-5 4-Methoxybenzyl alcohol 
• 150-76-5 4-methoxy-phenol 
• 79239-16-0 4-methoxybenzoic 3,5-dinitrobenzoic anhydride 
• 20950-96-3 (4-methoxyphenyl)carbamic acid phenyl ester 
• 30364-57-9 4-methoxybenzoic acid 2,5-dioxo-1-pyrrolidinyl ester 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 
• 849-83-2 bis(4-methoxybenzoyl) peroxide 
• 87662-94-0 O-benzoyl-N,N-dibutylhydroxylamine 
• 3400-22-4 4-methoxy-N-methylbenzamide 
• 97661-70-6 4-methoxy-N-methyl-N-nitrosobenzamide 
• 25393-52-6 3-(4-Methoxybenzoyl)-2-oxazolidinone 

Downstream Products

• 105-13-5 4-Methoxybenzyl alcohol 
• 3910-58-5 N-(4-methoxybenzyl)butan-1-amine 

Relevant articles and documents

Double carbonylation of aryl iodides with primary amines under atmospheric pressure conditions using the Pd/PPh3/DABCO/THF system

-

A CO2-Catalyzed Transamidation Reaction

Transamidation reactions are often mediated by reactive substrates in the presence of overstoichiometric activating reagents and/or transition metal catalysts. Here we report the use of CO2as a traceless catalyst: in the presence of catalytic amounts of CO2, transamidation reactions were accelerated with primary, secondary, and tertiary amide donors. Various amine nucleophiles including amino acid derivatives were tolerated, showcasing the utility of transamidation in peptide modification and polymer degradation (e.g., Nylon-6,6). In particular,N,O-dimethylhydroxyl amides (Weinreb amides) displayed a distinct reactivity in the CO2-catalyzed transamidation versus a N2atmosphere. Comparative Hammett studies and kinetic analysis were conducted to elucidate the catalytic activation mechanism of molecular CO2, which was supported by DFT calculations. We attributed the positive effect of CO2in the transamidation reaction to the stabilization of tetrahedral intermediates by covalent binding to the electrophilic CO2

Triethyl Phosphite/Benzoyl Peroxide Mediated Reductive Dealkylation of O-Benzoylhydroxylamines: A Cascade Synthesis of Secondary Amides

A new triethyl phosphite/benzoyl peroxide (BPO) mediated system has been developed for the synthesis of secondary amides with good to excellent yields in a single step. This unprecedented cascade process involves sequential reduction of N–O bond and benzoylation followed by dealkylation of N–C bond of O-benzoylhydroxylamines (O-BHA). The methodology is versatile as it tolerates a variety of aromatic and aliphatic O-BHA as substrates to access secondary amides.