39253-43-5

Basic information

• Product Name: N-(4-Methoxyphenyl)-4-methylbenzenamine
• Synonyms: (4-METHOXY-PHENYL)-P-TOLYL-AMINE;N-(4-Methoxyphenyl)-4-methylbenzenamine;4-Methoxy-4'-methyldiphenylamine;4-methoxy-N-4-tolylaniline;(4-Methoxy-phenyl)-p-tolylanMine;N-(4-Methoxyphenyl)-p-tolylamine;4-Methoxy-N-(p-tolyl)aniline;N-(4-Methoxyphenyl)-4-methylbenzemine
• CAS NO: 39253-43-5
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.27
• EINECS: 1533716-785-6
• Mol File: 39253-43-5.mol
• Article Data: 94

Chemical Properties

• Melting Point: 82.0 to 86.0 °C
• Boiling Point: 354.944 °C at 760 mmHg
• Flash Point: 143.714 °C
• Appearance: /
• Density: 1.09 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: N-(4-Methoxyphenyl)-4-methylbenzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methoxyphenyl)-4-methylbenzenamine(39253-43-5)
• EPA Substance Registry System: N-(4-Methoxyphenyl)-4-methylbenzenamine(39253-43-5)

Safety Data

• Hazardous Substances Data: 39253-43-5(Hazardous Substances Data)

Usage

General Description

N-(4-Methoxyphenyl)-4-methylbenzenamine is an organic compound, more specifically an aromatic amine. It is composed of a methoxyphenyl group (C6H5OCH3) and a methylbenzenamine group (C6H5NH2), both of which are bound to a central nitrogen atom. It is used primarily in the field of organic synthesis, where it can act as a building block for the production of more complex chemical structures. The compound's properties, like solubility, melting point, and boiling point, are generally defined by the nature of its aromatic rings and the presence of the amine and ether functional groups. Its exact properties and applications can vary greatly depending on the specific structure and configuration of the compound. Safety procedures should always be followed when handling it due to its potential toxicity.

InChI:InChI=1/C14H15NO/c1-11-3-5-12(6-4-11)15-13-7-9-14(16-2)10-8-13/h3-10,15H,1-2H3

Upstream product

• 106-43-4 para-chlorotoluene 
• 104-94-9 4-methoxy-aniline 
• 623-10-9 N-(4-methylphenyl)hydroxylamine 
• 100-66-3 methoxybenzene 
• 384842-24-4 dicyclohexyl(1,1-diphenyl-1-propen-2-yl)phosphine 
• 696-62-8 para-iodoanisole 
• 106-49-0 p-toluidine 
• 99-99-0 1-methyl-4-nitrobenzene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 80-48-8 methyl p-toluene sulfonate 
• 106-44-5 p-cresol 
• 100-17-4 para-methoxynitrobenzene 
• 1774-36-3 bis(4-methoxyphenyl) sulfoxide 
• 73774-45-5 di-(4-methoxyphenyl)borinic acid 

Downstream Products

• 59919-04-9 4-methoxy-N-methyl-N-(p-tolyl)aniline 
• 1378973-60-4 (E)-N-(1,3-diphenylallyl)-4-methoxy-N-p-tolylaniline 
• 1357929-84-0 C₈₁H₆₈N₄O₄ 
• 1357929-95-3 C₅₂H₇₂N₂O₆Si₆ 
• 1357929-92-0 C₄₈H₆₀N₂O₄Si₄ 
• 122527-64-4 C₄₀H₃₆N₂O₂ 

Relevant articles and documents

Transition metals in organic synthesis, part 82.1 First total synthesis of methyl 6-methoxycarbazole-3-carboxylate, glycomaurrol, the anti-TB active micromeline, and the furo[2,3-c]carbazole alkaloid eustifoline-D

The palladium(0)-catalyzed animation followed by palladium(II)-catalyzed oxidative cyclization of the resulting diarylamine provides a short route to a series of 6-oxygenated carbazole alkaloids: glycozoline, 3-formyl-6- methoxycarbazole, methyl 6-methoxy

(DiMeIHeptCl)Pd: A Low-Load Catalyst for Solvent-Free (Melt) Amination

(DiMeIHeptCl)Pd, a hyper-branched N-aryl Pd NHC catalyst, has been shown to be efficient at performing amine arylation reactions in solvent-free ("melt") conditions. The highly lipophilic environment of the alkyl chains flanking the Pd center serves as lubricant to allow the complex to navigate through the paste-like environment of these mixtures. The protocol can be used on a multi-gram scale to make a variety of aniline derivatives, including substrates containing alcohol moieties.

Electrochemical Reductive Arylation of Nitroarenes with Arylboronic Acids

The synthesis of diarylamine is extremely important in organic chemistry. Herein, a novel electrochemical reductive arylation of nitroarenes with arylboronic acids was developed. A variety of diarylamines were synthesized without the need for transition-metal catalysts. The reaction could be scaled up efficiently in a flow cell and several derivatization reactions were carried out smoothly. Cyclic voltammetry experiments and mechanism studies showed that acetonitrile, formic acid, and triethyl phosphite all played a role in promoting this reductive arylation transformation.