39745-17-0Relevant academic research and scientific papers
Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy
Zhou, Hui,Zeng, Xiaodong,Li, Anguo,Zhou, Wenyi,Tang, Lin,Hu, Wenbo,Fan, Quli,Meng, Xianli,Deng, Hai,Duan, Lian,Li, Yanqin,Deng, Zixin,Hong, Xuechuan,Xiao, Yuling
, (2020/12/07)
NIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted NIR-II dyes have not been reported. Herein, we report development of D-A type thiopyrylium-based NIR-II fluorophores with frequency upconversion luminescence (FUCL) at ~580 nm upon excitation at ~850 nm. H4-PEG-PT can not only quickly and effectively image mitochondria in live or fixed osteosarcoma cells with subcellular resolution at 1 nM, but also efficiently convert optical energy into heat, achieving mitochondria-targeted photothermal cancer therapy without ROS effects. H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-II signals with high spatial and temporal resolution, and remarkable NIR-II image-guided photothermal therapy. This report presents the first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and excellent photothermal efficiency.
Direct asymmetric Michael addition of ketones to chalcones catalyzed by a hydroxyphthalimide derived triazole-pyrrolidine
Kumar, Togapur Pavan,Sattar, Mohammad Abdul,Sarma, Vanka Uma Maheshwara
, p. 1615 - 1619 (2014/01/06)
An efficient protocol for the enantioselective Michael additions of ketones to chalcones catalyzed by a hydroxyphthalimide linked triazole-pyrrolidine derivative has been developed. The corresponding products, 1,5-dicarbonyl compounds, were obtained in good yields with high levels of stereoselectivities under mild reaction conditions employing benzoic acid as an additive.
Direct asymmetric michael additions of ketones to nitroolefins and chalcones catalyzed by a Chiral C2-symmetric pyrrolidine-based tetraamine
Ma, Shijun,Wu, Lulu,Liu, Ming,Wang, Yongmei
, p. 2707 - 2713 (2013/01/15)
C2-Symmetric pyrrolidine-based tetraamine, available from commercially starting materials, showed good catalytic activity for asymmetric Michael additions of ketones to nitroalkenes especially to chalcones. The reactions proceeded to give the corresponding products in good yields and in a highly selective manner.
Pyrrolidine-pyridine base catalysts for the enantioselective Michael addition of ketones to chalcones
Xu, Da-Zhen,Shi, Sen,Liu, Yingjun,Wang, Yongmei
experimental part, p. 9344 - 9349 (2010/01/06)
A series of pyrrolidine-pyridine base organocatalysts have been developed and 3a found to be a highly effective catalyst for the asymmetric Michael addition reactions of ketones to chalcones. The reaction generated the corresponding products 1, 5-diketone
Domino products from the reaction of 1,3-diaryl-2-propen-1-ones (chalcones) with cyclopentanone
Surya Prakash Rao,Jeyalakshmi,Bharathi,Pushpalatha,Umamaheswari
, p. 787 - 795 (2007/10/03)
The simple reaction of chalcones with cyclopentanone in the presence of barium hydroxide furnished complex domino products of the types 4 and 5 along with 1,5-diketones 3. Mechanistic considerations reveal that the bicyclic alcohol 4 was formed by sequent
Kinetics and Mechanisms of Nucleophilic Displacements with Heterocycles as Leaving Groups. 2. N-Benzylpyridinium Cations: Rate Variation with Steric Effects in the Leaving Group
Katritzky, Alan R.,El-Mowafy, Azzahra M.,Musumarra, Giuseppe,Sakizadeh, Kumars,Sana-Ullah, Choudhry,et al.
, p. 3823 - 3830 (2007/10/02)
N-Benzyl groups are transferred to piperidine from pyridinium ions by unimolecular SN1 and/or bimolecular SN2 mechanisms.Steric acceleration by α-phenyl groups is reduced by an adjacent β-methyl group but increased by constraining th
