400745-54-2

Basic information

• Product Name: 2'-METHYL [1,1'-BIPHENYL]-3-AMINE
• Synonyms: AKOS BAR-0115;2'-METHYL [1,1'-BIPHENYL]-3-AMINE;2'-METHYL-BIPHENYL-3-YLAMINE;CHEMBRDG-BB 4102396;(2'-methylbiphenyl-3-yl)amine(SALTDATA: HCl);3-AMino-2'-Methylbiphenyl;2'-methylbiphenyl-3-amine
• CAS NO: 400745-54-2
• Molecular Formula: C₁₃H₁₃N
• Molecular Weight: 183.25
• Mol File: 400745-54-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2'-METHYL [1,1'-BIPHENYL]-3-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-METHYL [1,1'-BIPHENYL]-3-AMINE(400745-54-2)
• EPA Substance Registry System: 2'-METHYL [1,1'-BIPHENYL]-3-AMINE(400745-54-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 400745-54-2(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
2'-METHYL [1,1'-BIPHENYL]-3-AMINE is used as a building block for the synthesis of pharmaceuticals. Its stability and reactivity make it suitable for the creation of novel and complex molecules with potential therapeutic applications.
Used in Agrochemicals:
2'-METHYL [1,1'-BIPHENYL]-3-AMINE is used as a component in the development of agrochemicals. Its unique structure can contribute to the design of new and effective compounds for agricultural use.
Used in Material Science:
2'-METHYL [1,1'-BIPHENYL]-3-AMINE is used as a precursor in the synthesis of organic materials. Its properties can be leveraged to develop new materials with beneficial characteristics for various applications.
Further research and development of 2'-METHYL [1,1'-BIPHENYL]-3-AMINE could lead to the discovery of new drugs and materials with beneficial properties, expanding its potential uses across different industries.

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Downstream Products

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Relevant articles and documents

DIARYLUREAS AS CB1 ALLOSTERIC MODULATORS

The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution

Allosteric modulators of the cannabinoid CB1 receptor have recently been reported as an alternative approach to modulate the CB1 receptor for therapeutic benefits. In this study, we report the design and synthesis of a series of diarylureas derived from PSNCBAM-1 (2). Similar to 2, these diarylureas dose-dependently inhibited CP55,940-induced intracellular calcium mobilization and [35S]GTP-γ-S binding while enhancing [3H]CP55,940 binding to the CB1 receptor. Structure-activity relationship studies revealed that the pyridinyl ring of 2 could be replaced by other aromatic rings and the pyrrolidinyl ring is not required for CB1 allosteric modulation. 34 (RTICBM-74) had similar potencies as 2 in all in vitro assays but showed significantly improved metabolic stability to rat liver microsomes. More importantly, 34 was more effective than 2 in attenuating the reinstatement of extinguished cocaine-seeking behavior in rats, demonstrating the potential of this diarylurea series as promising candidates for the development of relapse treatment of cocaine addiction.

NOVEL ORGANIC COMPOUND, MATERIAL COMPRISING THE SAME FOR ORGANIC ELECTROLUMINESCENCE DEVICES, AND ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE MATERIAL

The present invention provides a novel organic compound of General Formula 1, a material comprising the same for organic electroluminescence devices, and an organic electroluminescence device comprising the material. The organic compound of the present invention is useful in organic electroluminescence devices as a hole injection layer substance, a hole transport layer substance, an electron blocking layer substance, and an emission layer substance such as green and red phosphorescent host substance, and when used in the organic electroluminescence devices, can reduce the drive voltage, and increase the luminous efficiency, luminance, thermal stability, color purity and service life of the devices.

NOVEL ORGANIC COMPOUND, MATERIAL COMPRISING THE SAME FOR ORGANIC ELECTROLUMINESCENCE DEVICES, AND ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE MATERIAL

The present invention provides a novel organic compound, a material comprising the same for organic electroluminescence devices, and an organic electroluminescence device comprising the material. The organic compound provided in the present invention is useful in organic electroluminescence devices as a hole injection layer material, a hole transport layer material, an electron blocking layer material, and an emission layer material such as green and red phosphorescent host material, and can reduce the drive voltage, and increase the luminous efficiency, luminance, thermal stability, color purity and service life of the devices.

Pd/mannose promoted tandem cross coupling-nitro reduction: Expedient synthesis of aminobiphenyls and aminostilbenes

The dual role of d-mannose as a ligand for Pd catalyzed cross-coupling, and as a hydrogen source for nitro reduction is demonstrated in a modular cross coupling-nitro reduction sequence. The synthetic utility and generality of this green protocol has been illustrated by the synthesis of 20 aminobiphenyl and 10 aminostilbene derivatives in high yields through a one-pot Suzuki coupling-nitro reduction and a Heck coupling-nitro reduction, respectively, starting from halonitroarenes as substrates.

A highly active and general catalyst for the stille coupling reaction of unreactive aryl, heteroaryl, and vinyl chlorides under mild conditions

A β-diketiminatophosphane-palladium complex was found to act as an efficient and general catalyst in the Stille coupling reaction of various aryl and heteroaryl chlorides with organostannanes. The results show that this catalytic system allows for the use of less reactive substrates such as deactivated or sterically hindered aryl chlorides. A catalyst loading of 0.5 mol% was sufficient to achieve excellent performance under relatively mild reaction conditions. Furthermore, the scope of catalyst was extended to the coupling of vinyl chlorides. Copyright

METAL COMPLEXES COMPRISING AZABENZIMIDAZOLE CARBENE LIGANDS AND THE USE THEREOF IN OLEDS

The present invention relates to metal-carbene complexes comprising a central atom selected from iridium and platinum, and specific azabenzimidazolocarbene ligands, to OLEDs (Organic Light Emitting Diode, OLED) which comprise such complexes, to a device selected from the group consisting of illuminating elements, stationary visual display units and mobile visual display units comprising such an OLED, to the use of such a metal-carbene complex in OLEDs, for example as emitter, matrix material, charge transport material and/or charge or exciton blocker.

General and highly active catalyst for mono and double Hiyama coupling reactions of unreactive aryl chlorides in water

A new β-diketiminatophosphane Pd catalyst was found to be highly effective in the mono and double Hiyama coupling reactions of unactivated aryl chlorides in water.

Structurally simple inhibitors of lanosterol 14α-demethylase are efficacious in a rodent model of acute Chagas disease

We report structure-activity studies of a large number of dialkyl imidazoles as inhibitors of Trypanosoma cruzi lanosterol-14α-demethylase (L14DM). The compounds have a simple structure compared to posaconazole, another L14DM inhibitor that is an anti-Chagas drug candidate. Several compounds display potency for killing T. cruzi amastigotes in vitro with values of EC 50 in the 0.4-10 nM range. Two compounds were selected for efficacy studies in a mouse model of acute Chagas disease. At oral doses of 20-50 mg/kg given after establishment of parasite infection, the compounds reduced parasitemia in the blood to undetectable levels, and analysis of remaining parasites by PCR revealed a lack of parasites in the majority of animals. These dialkyl imidazoles are substantially less expensive to produce than posaconazole and are appropriate for further development toward an anti-Chagas disease clinical candidate.