40281-50-3

Basic information

• Product Name: 3'-FLUORO-2-PHENYLACETOPHENONE
• Synonyms: 3'-FLUORO-2-PHENYLACETOPHENONE;1-(3-Fluorophenyl)-2-phenylethanone
• CAS NO: 40281-50-3
• Molecular Formula: C₁₄H₁₁FO
• Molecular Weight: 214.23
• Mol File: 40281-50-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 327.4°C at 760 mmHg
• Flash Point: 135.3°C
• Appearance: /
• Density: 1.152g/cm³
• Vapor Pressure: 0.000202mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 3'-FLUORO-2-PHENYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-FLUORO-2-PHENYLACETOPHENONE(40281-50-3)
• EPA Substance Registry System: 3'-FLUORO-2-PHENYLACETOPHENONE(40281-50-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 40281-50-3(Hazardous Substances Data)

Usage

General Description

3'-Fluoro-2-phenylacetophenone is a synthetic compound with the chemical formula C14H11FO. This organic compound belongs to the class of aromatic ketones, which are known for their diverse applications in the chemical and pharmaceutical industries. The presence of a fluorine atom in the 3' position of the molecule enhances its chemical reactivity and influences its physical properties. 3'-Fluoro-2-phenylacetophenone can be used as a building block in organic synthesis to create more complex molecules, and it may also have potential applications in medicinal chemistry as a starting material for the development of new pharmaceutical drugs. Additionally, it has been studied for its distinctive properties in terms of its chemical behavior and interactions with other molecules.

InChI:InChI=1/C14H11FO/c15-13-8-4-7-12(10-13)14(16)9-11-5-2-1-3-6-11/h1-8,10H,9H2

Upstream product

• 1398057-04-9 1-(1-azidovinyl)-3-fluorobenzene 
• 100-63-0 phenylhydrazine 
• 1996-38-9 3-fluorobenzenediazonium tetrafluoroborate 
• 4747-15-3 1-(2-methoxyvinyl)benzene 
• 100-52-7 benzaldehyde 
• 455-68-5 methyl 3-fluorobenzoate 
• 108-88-3 toluene 
• 1711-07-5 3-fluorobenzoyl chloride 
• 456-48-4 3-Fluorobenzaldehyde 
• 100-39-0 benzyl bromide 
• 100948-28-5 2-(3-fluorophenyl)-2-((trimethylsilyl)oxy)acetonitrile 
• 108-86-1 bromobenzene 
• 455-36-7 1-(3-fluorophenyl)ethanone 
• 768-35-4 3-fluorophenylboronic acid 

Downstream Products

• 185345-82-8 4-[2-(4-fluorophenyl)-2-oxoethyl]-1-benzenesulfonamide 
• 394-74-1 2-benzyl-3'-fluoro-benzophenone 
• 1283117-41-8 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(3-fluorophenyl)-5-phenyl-3,4-dihydropyrimidi-2(1H)-one 
• 959407-69-3 1-(3-fluoro-phenyl)-2-phenyl-ethylamine 

Relevant articles and documents

Visible-Light-Promoted [3 + 2] Cycloaddition of 2H-Azirines with Quinones: Access to Substituted Benzo[f]isoindole-4,9-diones

A visible-light-promoteded [3 + 2] cycloaddition reaction of 2H-azirines with quinones has been developed under mild reaction conditions. The reaction provides a general and efficient strategy for the synthesis of the benzo[f]isoindole-4,9-diones scaffold

Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature

Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.

Synthesis of unsymmetrical ketones by applying visible-light benzophenone/nickel dual catalysis for direct benzylic acylation

Herein, we report a dual catalytic system for the direct benzylic C-H acylation reaction furnishing a variety of unsymmetrical ketones. A benzophenone-derived photosensitizer combined with a nickel catalyst has been established as the catalytic system. Both acid chlorides and anhydrides are able to acylate the benzylic position of toluene and other methylbenzenes. The method offers a valuable alternative to late transition metal catalyzed C-H acylation reactions.