402822-97-3

Upstream product

• 110674-68-5 1-phenyl-N-(2-(prop-1-en-2-yl)phenyl)methanimine 
• 134-20-3 2-carbomethoxyaniline 
• 15833-00-8 o-aminophenyldimethylcarbinol 
• 490035-95-5 N-benzyl-2-(prop-1-en-2-yl)benzen-amine 
• 100-39-0 benzyl bromide 
• 52562-19-3 2-isopropenylaniline 
• 402822-93-9 N-allyl-N-benzyl-2-(1-methylvinyl)aniline 

Downstream Products

• 1448670-20-9 5-methyl-11-phenylisoindolo[2,1-a]quinoline-7,10-dione 
• 1448670-30-1 5-methyl-13-phenylbenzo[5,6]isoindolo[2,1-a]quinoline-7,12-dione 
• 491-35-0 C₆H₄NCH₂CHCCH₂ 

Relevant academic research and scientific papers

One-pot ring-closing metathesis/1,3-dipolar cycloaddition through assisted tandem ruthenium catalysis: Synthesis of a dye with isoindolo[2,1-a]quinoline structure

The one-pot tandem reaction of N-alkyl-N-allyl-2-vinylaniline derivatives with benzo- or naphthoquinones and a ruthenium-alkylidene catalyst leads to isoindolo[2,1-a]quinolines in a variety of colors, which can be altered by exchanging the substituent on the core heterocycle (see scheme). This reaction offers a new synthetic method for π-conjugated small molecules from simple aniline derivatives. Copyright

A novel synthesis of substituted quinolines using ring-closing metathesis (RCM): Its application to the synthesis of key intermediates for anti-malarial agents

A method for synthesizing substituted quinolines using ruthenium-catalyzed ring-closing metathesis as a key step has been developed. Substituted 1,2-dihydroquinolines, 4-silyloxy-1,2-dihydroquinoline and 4-methoxy-1,2- dihydroquinoline, were successfully synthesized in excellent yields via ene-ene metathesis and silyl or alkyl enol ether-ene metathesis, respectively. The synthetic intermediates of the antimalarial agents quinine, chloroquine, and PPMP-quinine hybrid were efficiently synthesized by this methodology.

Synthesis of substituted 1,2-dihydroquinolines and quinolines using ene-ene metathesis and ene-enol ether metathesis

We describe a novel and convenient method for quinoline synthesis using ring-closing olefin metathesis (RCM), ene-ene metathesis, and ene-enol ether metathesis. We also report the first example of enol silyl ether-ene metathesis to produce cyclic enol silyl ether. Using this method, versatile substituted quinoline derivatives were readily prepared in excellent yield from anthranilic acid derivatives.