15833-00-8Relevant articles and documents
Organocatalytic Atroposelective Construction of Axially Chiral N-Aryl Benzimidazoles Involving Carbon-Carbon Bond Cleavage
Man, Ningning,Lou, Zhenbang,Li, Yuming,Yang, Haijun,Zhao, Yufen,Fu, Hua
supporting information, p. 6382 - 6387 (2020/09/02)
Axially chiral compounds widely occur in natural products, biologically active molecules, ligands, and catalysts, and their efficient and enantioselective synthesis is highly desirable. Herein, we report a novel method for the atroposelective construction of axially chiral N-aryl benzimidazoles with chiral phosphoric acid as the organocatalyst via reaction of N1-(aryl)benzene-1,2-diamines with multicarbonyl compounds. The present method provided the target products in high yields (up to 89percent) with excellent enantioselectivity (up to 98percent ee).
Phosphorescent organic compound, preparation method thereof and organic electroluminescent device
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Paragraph 0034-0038; 0050-0054; 0058-0062, (2020/12/30)
The invention discloses a phosphorescent organic compound, a preparation method of the phosphorescent organic compound and an organic electroluminescent device, and belongs to the field of chemical synthesis and photoelectric materials. The structural gen
CALICHEAMICIN DERIVATIVES AND ANTIBODY DRUG CONJUGATES THEREOF
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Page/Page column 193, (2018/08/20)
The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.