40643-55-8

Basic information

• Product Name: 2-[METHYL(PHENYL)AMINO]ACETIC ACID
• Synonyms: N-methyl-N-phenylglycine hydrochloride;glycine, N-methyl-N-phenyl-;N-phenyl-N-methylglycine;N-methyl-N-phenylglycine(SALTDATA: HCl);(Methyl-phenyl-aMino)-acetic acid;2-[Methyl(phenyl)aMino]acetic acid hydrochloride
• CAS NO: 40643-55-8
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Mol File: 40643-55-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 270 °C (sublm)(Solv: water (7732-18-5))
• Boiling Point: 311.6°C at 760 mmHg
• Flash Point: 142.3°C
• Appearance: /
• Density: 1.192g/cm³
• Vapor Pressure: 0.000238mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: 2-8°C
• PKA: 1.77±0.10(Predicted)
• CAS DataBase Reference: 2-[METHYL(PHENYL)AMINO]ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[METHYL(PHENYL)AMINO]ACETIC ACID(40643-55-8)
• EPA Substance Registry System: 2-[METHYL(PHENYL)AMINO]ACETIC ACID(40643-55-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 40643-55-8(Hazardous Substances Data)

Usage

General Description

2-[Methyl(phenyl)amino]acetic acid is a chemical compound with the molecular formula C9H11NO2. It is a derivative of acetic acid and contains a methylamino group attached to the alpha carbon of the acetic acid moiety. 2-[METHYL(PHENYL)AMINO]ACETIC ACID has a molecular weight of 165.19 g/mol and is a white to off-white powder at room temperature. It has potential applications in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical compounds. Additionally, it may also have applications in organic synthesis and medicinal chemistry research.

InChI:InChI=1/C9H11NO2/c1-10(7-9(11)12)8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H,11,12)

Upstream product

• 64-17-5 ethanol 
• 100-61-8 N-methylaniline 
• 7647-01-0 hydrogenchloride 
• 103-01-5 N-Phenylglycine 
• 74-88-4 methyl iodide 
• 20059-60-3 N-methyl-N-p-phenylglycine methyl ester 
• 591-50-4 iodobenzene 
• 107-97-1 sarcosine 
• 100-46-9 benzylamine 
• 21911-74-0 (methyl-phenyl-amino)-acetic acid ethyl ester 
• 517-21-5 glyoxal sodium bisulfite 
• 3926-62-3 sodium monochloroacetic acid 
• 79-11-8 chloroacetic acid 
• 95-53-4 o-toluidine 

Downstream Products

• 97641-43-5 N-(3,3-diphenylpropyl)-N-methylaniline 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 91429-74-2 N,N-dimethyl-2-(methyl(phenyl)amino)acetamide 
• 98-86-2 acetophenone 
• 629621-75-6 4-chlorobenzyl N-methyl-N-phenylglycinate 
• 121-69-7 N,N-dimethyl-aniline 
• 15719-64-9 methylammonium carbonate 

Relevant articles and documents

Access to α-Amino Acid Esters through Palladium-Catalyzed Oxidative Amination of Vinyl Ethers with Hydrogen Peroxide as the Oxidant and Oxygen Source

A novel and convenient palladium catalytic system for the synthesis of α-amino acid esters from simple starting materials is reported. Hydrogen peroxide not only acts as the green oxidant, but also as the oxygen source. This strategy for the conversion of amines and vinyl ethers into highly functionalized and structurally diverse α-amino acid esters is characterized by the simplicity of the experimental procedure, mild reaction conditions, high atom economy, scalability, and practicability.

Iron-catalyzed oxidative amidation of tertiary amines with aldehydes

Unconventional couple: A new oxidative coupling protocol for amide bond formation has been developed (see scheme). The method provides an efficient and practical route for the synthesis of tertiary amides from readily available tertiary amines and aldehydes in the presence of a simple FeCl2 catalyst. Mechanistic studies indicated that a peroxide and an iminium ion act as the reactive intermediates in this oxidative amidation.

Mild method for ullmann coupling reaction of amines and aryl halides

(Matrix presented) Ullmann-type aryl amination of aryl iodides and aryl bromides in DMSO at 40-90°C gave the corresponding N-arylamines or N,N-diarylamines in good to excellent yields by using either N-methylglycine or L-proline as the ligand.