40643-55-8

Usage

Uses

Used in Pharmaceutical Industry:
2-[METHYL(PHENYL)AMINO]ACETIC ACID is used as a building block for the synthesis of various pharmaceutical compounds due to its unique chemical structure and properties. It plays a crucial role in the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2-[METHYL(PHENYL)AMINO]ACETIC ACID is utilized as a key intermediate for the preparation of a wide range of organic compounds. Its versatile structure allows for various chemical reactions, enabling the creation of diverse molecules with potential applications in different industries.
Used in Medicinal Chemistry Research:
2-[METHYL(PHENYL)AMINO]ACETIC ACID is employed as a valuable research tool in medicinal chemistry. It aids scientists in understanding the structure-activity relationships of various biologically active molecules and contributes to the discovery of novel therapeutic agents with improved efficacy and safety profiles.

InChI:InChI=1/C9H11NO2/c1-10(7-9(11)12)8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H,11,12)

Upstream product

• 191789-56-7 2-(o-tolylamino)acetamide 
• 105-39-5 chloroacetic acid ethyl ester 
• 121-69-7 N,N-dimethyl-aniline 
• 3926-62-3 sodium monochloroacetic acid 
• 100-61-8 N-methylaniline 
• 517-21-5 glyoxal sodium bisulfite 
• 21911-74-0 (methyl-phenyl-amino)-acetic acid ethyl ester 
• 64-17-5 ethanol 
• 7647-01-0 hydrogenchloride 
• 591-50-4 iodobenzene 
• 107-97-1 sarcosine 
• 100-46-9 benzylamine 
• 103-01-5 N-Phenylglycine 
• 74-88-4 methyl iodide 

Downstream Products

• 121-69-7 N,N-dimethyl-aniline 
• 15719-64-9 methylammonium carbonate 
• 98-86-2 acetophenone 
• 97641-43-5 N-(3,3-diphenylpropyl)-N-methylaniline 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 91429-74-2 N,N-dimethyl-2-(methyl(phenyl)amino)acetamide 
• 629621-75-6 4-chlorobenzyl N-methyl-N-phenylglycinate 

Relevant academic research and scientific papers

Access to α-Amino Acid Esters through Palladium-Catalyzed Oxidative Amination of Vinyl Ethers with Hydrogen Peroxide as the Oxidant and Oxygen Source

A novel and convenient palladium catalytic system for the synthesis of α-amino acid esters from simple starting materials is reported. Hydrogen peroxide not only acts as the green oxidant, but also as the oxygen source. This strategy for the conversion of amines and vinyl ethers into highly functionalized and structurally diverse α-amino acid esters is characterized by the simplicity of the experimental procedure, mild reaction conditions, high atom economy, scalability, and practicability.

1,2-NAPHTHOQUINONE DERIVATIVE AND METHOD FOR PREPARING SAME

Disclosed are a compound represented by Formula (1), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, tautomer, enantiomer, or pharmaceutically acceptable diastereomer thereof, a method of preparing the same, and a pharmaceutical composition, which have effects for treatment or prevention of metabolic syndromes, comprising the same: wherein R1to R6, X1 to X4, and n are the same as defined in Claim 1.

Iron-catalyzed oxidative amidation of tertiary amines with aldehydes

Unconventional couple: A new oxidative coupling protocol for amide bond formation has been developed (see scheme). The method provides an efficient and practical route for the synthesis of tertiary amides from readily available tertiary amines and aldehydes in the presence of a simple FeCl2 catalyst. Mechanistic studies indicated that a peroxide and an iminium ion act as the reactive intermediates in this oxidative amidation.

Ruthenium-catalyzed oxidative cyanation of tertiary amines with molecular oxygen or hydrogen peroxide and sodium cyanide: Sp3 C-H bond activation and carbon-carbon bond formation

Ruthenium-catalyzed oxidative cyanation of tertiary amines with molecular oxygen in the presence of sodium cyanide and acetic acid gives the corresponding α-aminonitriles, which are highly useful intermediates for organic synthesis. The reaction is the first demonstration of direct sp3 C-H bond activation α to nitrogen followed by carbon-carbon bond formation under aerobic oxidation conditions. The catalytic oxidation seems to proceed by (i) α-C-H activation of tertiary amines by the ruthenium catalyst to give an iminium ion/ruthenium hydride intermediate, (ii) reaction with molecular oxygen to give an iminium ion/ruthenium hydroperoxide, (iii) reaction with HCN to give the α-aminonitrile product, H2O2, and Ru species, (iv) generation of oxoruthenium species from the reaction of Ru species with H2O2, and (v) reaction of oxoruthenium species with tertiary amines to give α-aminonitriles. On the basis of the last two pathways, a new type of ruthenium-catalyzed oxidative cyanation of tertiary amines with H2O2 to give α-aminonitriles was established. The α-aminonitriles thus obtained can be readily converted to α-amino acids, diamines, and various nitrogen-containing heterocyclic compounds.

Mild method for ullmann coupling reaction of amines and aryl halides

(Matrix presented) Ullmann-type aryl amination of aryl iodides and aryl bromides in DMSO at 40-90°C gave the corresponding N-arylamines or N,N-diarylamines in good to excellent yields by using either N-methylglycine or L-proline as the ligand.

ANILINO LIVER X-RECEPTOR MODULATORS

The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula I and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically effective dose of a compound of Formula I.

Aerobic Ruthenium-Catalyzed Oxidative Cyanation of Tertiary Amines with Sodium Cyanide

RuCl3-catalyzed oxidative cyanation of tertiary amines with sodium cyanide under molecular oxygen (1 atm) at 60 °C gives the corresponding α-aminonitriles, which are versatile synthetic intermediates of various compounds such as amino acids and

HIV protease inhibitors based on amino acid derivatives

A compound selected from the group consisting of a compound of formula I 1a compound of formula II 2and when the compound of formula I and II comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1, R2, Cx, n, R3, R4, R5, Y are as defined in the specification.

Piperidine derivatives with PAF antagonist activity

Compounds of general formula I and their salts and solvates are PAF antagonists and as such are useful in the treatment of various diseases or disorders mediated by PAF. Pharmaceutical compositions including these compounds and processes for their prepara

SYNTHESIS OF BAPTA-AM ANALOGUES CAPABLE OF ENHANCING THE VASCULAR PRODUCTION OF PROSTACYCLIN

About 30 analogues of BAPTA-AM, a potential antithrombotic agent, have been synthesized and tested for their effect on the production of prostacyclin.None of them was found to be a better enhancher of the production of prostacyclin by aortic endothelial cells than BAPTA-AM itself.The enhancing effect can be produced by compounds unable to chelate Ca2+, thus confirming that it is not related to their buffering capacity for free Ca2+.