40746-65-4

Upstream product

• 14368-49-1 p-nitrobenzenediazonium 
• 500890-29-9 N’-acetyl-4-(dimethylamino)benzohydrazide 
• 22815-97-0 N’-acetyl-4-chlorobenzohydrazide 
• 100-05-0 4-nitrobenzenediazonium chloride 
• 54019-08-8 4-methoxy-benzoic acid N'-acetyl-hydrazide 
• 82122-73-4 N-acetyl-N'-phenylacetylhydrazine 
• 186818-30-4 N’-acetyl-4-methylbenzohydrazide 
• 4076-36-2 5-methyl-1,2,3,4-tetrazole 
• 350-46-9 4-Fluoronitrobenzene 
• 934168-30-6 N-(1-chloroethylidene)-4-nitrobenzenamine 
• 14213-16-2 5-methyl-1-phenyl-1H-tetrazole 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 1194641-40-1 3-(4-methylphenyl)-5-(5-methyl-1H-tetrazol-1-yl)-2,1-benzisoxazole 
• 1083223-71-5 5-(5-methyl-1H-tetrazol-1-yl)-3-phenyl-2,1-benzisoxazole 
• 1083403-33-1 3-(4-chlorophenyl)-5-(5-methyl-1H-tetrazol-1-yl)-2,1-benzisoxazole 
• 49819-79-6 1,2-dimethyl-5-nitro-1H-benzimidazole 
• 19492-66-1 1,2-dimethyl-6-nitro-1H-benzoimidazole 
• 1821-27-8 N,N-bis(p-nitrophenyl)amine 
• 100-01-6 4-nitro-aniline 
• 1792-40-1 6-nitro-2-methyl-1H-benzimidazole 
• 100-15-2 N-methyl(p-nitroaniline) 

Relevant academic research and scientific papers

An efficient synthesis of nitrile, tetrazole and urea from carbonyl compounds

An efficient conversion of carbonyl compounds (aldehydes and ketones) to nitrile, tetrazole, and urea was developed with the use of a POCl3 and sodium azide mixture using a convergent and microwave method. This is the first report on the direct conversion of ketone to urea. The synthesized compounds were characterized by 1H NMR, 13C NMR, mass and IR spectroscopies and were found to be in agreement with reported compounds.

Kinetics and mechanism of 1-phenyl-5-methyltetrazole nitration in HNO3–H2SO4system

At nitration of 1-phenyl-5-methyltetrazole with nitric acid in aqueous solutions of sulfuric acid of 84–96% concentration a mixture forms of 1-(4-nitrophenyl)- and 1-(3-nitrophenyl)-5-methyltetrazoles in a ratio 60: 40. According to kinetic data, the tetrazole ring in the substrate is present in a protonated form. The protonation constants of 1-(4-carboxyphenyl)-5-methyltetrazole at the tetrazole ring and the carboxy group were determined. The Hammet’s electronic constant of the protonated tetrazole ring was calculated.

Synthesis of 2,1-benzisoxazoles by nucleophilic substitution of hydrogen in nitroarenes activated by the azole ring

Reaction of 1-nitro-4-(1,2,3-triazolyl/tetrazolyl)benzenes with arylacetonitriles in an alcoholic medium in the presence of excess alkali gives novel 2,1-benzisoxazoles. These findings indicate a high reactivity of nitroarenes activated by the azole ring due to their electron-deficient character. Moreover, it was found that annulation of the isoxazole ring occurred regioselectively in disubstituted nitroarenes. In the case of 1-(4-nitrophenyl)-1H-tetrazole, the tetrazole ring cleaved faster than the sH-adduct was formed. Georg Thieme Verlag Stuttgart.

SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT

Substituted cyclopropyl compounds of formula (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.