4097-63-6Relevant articles and documents
Synthesis of tripeptide mimetics based on dihydroquinolinone and benzoxazinone scaffolds
Dantas De Araujo, Aline,Christensen, Caspar,Buchardt, Jens,Kent, Stephen B. H.,Alewood, Paul F.
supporting information; experimental part, p. 13983 - 13986 (2012/01/06)
In the image: The design and synthesis of peptidomimetics that maintain the configuration of the triad Asp-Thr-Gly found in the catalytic site of the HIV-1 protease (see scheme) are described. By using regioselective nitration and reductive lactamisation,
On the synthesis of two dimethoxy-1,3,4,5-tetrahydropyrrolo[4,3,2-de]quinoline regioisomers
Chackal, Sarah,Dudouit, Fabienne,Houssin, Raymond,Henichart, Jean-Pierre
, p. 615 - 622 (2007/10/03)
Many marine alkaloids are biologically active products and possess the 1,3,4,5-tetrahydropyrrolo[4,3,2-de]quinoline core as a common feature. This is a report of the synthesis of two of the title molecules with confirmation of their structure.
Reaction of Ferulic Acid with Nitrite: Formation of 7-Hydroxy-6-methoxy-1,2(4H)-benzoxazin-4-one
Rousseau, Brigitte,Rosazza, John P. N.
, p. 3314 - 3317 (2007/10/03)
Ferulic acid was reacted with nitrite under acidic conditions to give complex mixtures of products. Chromatographic purification afforded products that were characterized by 1H- and 13C-NMR spectral analyses. The major fluorescent product was identified as 7-hydroxy-6-methoxy-1,2(4H)-benzoxazin-4-one along with 3-methoxy-4-hydroxybenzaldehyde (vanillin) and 2-methoxy-4,6-dinitrophenol. The structure of the unusual benzoxazinone was confirmed by its chemical degradation in base to methyl-2,4-dihydroxy-5-methoxybenzoic acid.
