42429-20-9

Basic information

• Product Name: N-Acetyl-L-phenylglycine
• Synonyms: N-Acetyl-L-phenylglycine;(2S)-2-(Acetylamino)-2-phenylacetic acid;(2S)-2-Acetylamino-2-phenylacetic acid;(S)-(Acetylamino)phenylacetic acid;(αS)-α-(Acetylamino)benzeneacetic acid;Benzeneacetic acid, a-(acetylaMino)-, (S)-;(S)-N-Acetyl-2-phenylglycine;N-Acetyl-(S)-2-phenylglycine
• CAS NO: 42429-20-9
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.2
• Mol File: 42429-20-9.mol
• Article Data: 45

Chemical Properties

• Appearance: /
• Density: 1.233
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-Acetyl-L-phenylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl-L-phenylglycine(42429-20-9)
• EPA Substance Registry System: N-Acetyl-L-phenylglycine(42429-20-9)

Safety Data

• Hazardous Substances Data: 42429-20-9(Hazardous Substances Data)

Usage

General Description

N-Acetyl-L-phenylglycine is a chemical compound that is derived from the amino acid phenylglycine. It is a white crystalline powder that is often used in the synthesis of pharmaceuticals and other organic compounds. N-Acetyl-L-phenylglycine is known for its ability to act as a chiral auxiliary in asymmetric synthesis, where it can help to form molecules with a specific spatial arrangement of atoms. It is also used in the preparation of N-alkyl amino acids and peptidomimetics, which are compounds designed to mimic the structure and function of peptides. N-Acetyl-L-phenylglycine has potential applications in the pharmaceutical and biotechnology industries due to its versatile nature and ability to facilitate the synthesis of complex molecules.

Upstream product

• 75-05-8 acetonitrile 
• 298-12-4 Glyoxilic acid 
• 71-43-2 benzene 
• 60-35-5 acetamide 
• 201230-82-2 carbon monoxide 
• 100-52-7 benzaldehyde 
• 2835-06-5 phenylglycin 
• 131934-09-3 ethyl 2-(hydroxyimino)-2-phenylacetate 
• 14257-84-2 N-acetyl-α-phenylglycine 
• 162247-66-7 2-Methyl-5-oxo-4-phenyl-4,5-dihydro-oxazole-4-carboxylic acid ethyl ester 
• 3076-54-8 phenyllead(IV) triacetate 
• 154614-38-7 (+/-)-N-1-acetyl-1-phenyl-2-propenylamine 
• 14304-68-8 N-Acetyl-α-phenylglycine ethyl ester 
• 2935-35-5 (S)-2-phenylglycine 

Downstream Products

• 573-34-2 2,4,5-triphenyloxazole 
• 885-75-6 2-amino-1,2-diphenyl-ethanone; hydrochloride 
• 107624-90-8 2-hydroxy-2-phenyl-1-[4]pyridyl-ethanone 
• 40061-64-1 2-hydroxy-2-phenyl-1-[3]pyridyl-ethanone 
• 14257-84-2 (S)-N-acetyl-2-phenylglycine 
• 6368-17-8 N-<α-Phenyl-α-(N-acetylamino)-acetyl>-aminoacetonitril 
• 14257-84-2 N-acetyl-α-phenylglycine 
• 130624-93-0 (D)-N^α-acetyl-(3-aminocyclohexyl)glycine 
• 112229-46-6 2-(R)-acetamido-2-(4'-aminocyclohexyl)-acetic acid 
• 112229-46-6 cis-(D)-N^α-acetyl-(4-aminocyclohexyl)glycine 
• 130624-88-3 cis-(DL)-4-hydroxycyclohexylglycine benzyl ester 
• 86296-96-0 1-Acetyl-5-methyl-2,4-diphenyl-1H-pyrrole-3-carbonitrile 
• 90421-37-7 N-(2-Cyano-4-oxo-1-phenyl-pentyl)-acetamide 
• 90421-39-9 N-(2-Cyano-2-methyl-4-oxo-1-phenyl-pentyl)-acetamide 

Relevant articles and documents

GRANZYME B DIRECTED IMAGING AND THERAPY

Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.

Regiodivergent Enantioselective γ-Additions of Oxazolones to 2,3-Butadienoates Catalyzed by Phosphines: Synthesis of α,α-Disubstituted α-Amino Acids and N,O-Acetal Derivatives

Phosphine-catalyzed regiodivergent enantioselective C-2- and C-4-selective γ-additions of oxazolones to 2,3-butadienoates have been developed. The C-4-selective γ-addition of oxazolones occurred in a highly enantioselective manner when 2-aryl-4-alkyloxazol-5-(4H)-ones were employed as pronucleophiles. With the employment of 2-alkyl-4-aryloxazol-5-(4H)-ones as the donor, C-2-selective γ-addition of oxazolones took place in a highly enantioselective manner. The C-4-selective adducts provided rapid access to optically enriched α,α-disubstituted α-amino acid derivatives, and the C-2-selective products led to facile synthesis of chiral N,O-acetals and γ-lactols. Theoretical studies via DFT calculations suggested that the origin of the observed regioselectivity was due to the distortion energy that resulted from the interaction between the nucleophilic oxazolide and the electrophilic phosphonium intermediate.

Convenient method for reduction of C-N double bonds in oximes, imines, and hydrazones using sodium Borohydride-Raney ni system

(Chemical Equation Presented) A practical method has been developed for reduction of C-N double bond in oximes, imines, and hydrazones with sodium borohydride catalyzed by Raney Ni. The reactions were carried out in basic aqueous solution, and the desired products were obtained in moderate yields after a simple procedure. This method can be applied to synthesize simpler aliphatic or aromatic amines and its analogs. Copyright Taylor & Francis Group, LLC.