42729-96-4Relevant articles and documents
Small-molecules that covalently react with a human prolyl hydroxylase-towards activity modulation and substrate capture
Bush, Jacob T.,Le?niak, Robert K.,Yeh, Tzu-Lan,Belle, Roman,Kramer, Holger,Tumber, Anthony,Chowdhury, Rasheduzzaman,Flashman, Emily,Mecinovi?, Jasmin,Schofield, Christopher J.
, p. 1020 - 1023 (2019/01/28)
We describe covalently binding modulators of the activity of human prolyl hydroxylase domain 2 (PHD2) and studies towards a strategy for photocapture of PHD2 substrates. Reversible active site binding of electrophile bearing compounds enables susbsequent covalent reaction with a lysine residue (K408) in the flexible C-terminal region of PHD2 to give a modified protein that retains catalytic activity.
A highly efficient strategy for the synthesis of 3-substituted salicylic acids by either directed ortho-lithiation or halogen-metal exchange of substituted mom protected phenols followed by carboxylation
Lau, Stephen Y.W.,Keay, Brian A.
, p. 1541 - 1545 (2007/10/03)
A highly efficient synthesis of various 3-substituted salicylic acids is described starting from inexpensive starting materials and requiring no special apparatus.
Microwave-assisted rapid Claisen rearrarangement on solid phase
Kumar,Anjaneyulu,Reddy,Yadav
, p. 1129 - 1130 (2007/10/03)
O-Allylsalicylic acids anchored to merrifield resin, are rapidly rearranged to the corresponding ortho-allylsalicylic acids in high yields for the first time under microwave irradiation.
2,3-Dihydro-7-benzofurancarboxylic Acids
Stanetty, Peter,Koller, Herbert,Puerstinger, Gerhard
, p. 883 - 891 (2007/10/02)
The syntheses of a series of title compounds 1 a-f bearing methyl groups in the heterocyclic part were described.Depending on the substitution pattern the Claisen rearrangement (path A) or the methodology of directed lithiations (path B) were used as the
