875798-79-1

Basic information

• Product Name: 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 3-(4-AMINOPHENYL)PIPERIDINE-1-CARBOXYLATE;N-BOC-3-(4-AMINOPHENYL) PIPERIDINE;1-Boc-3-(4-Aminophenyl)
• CAS NO: 875798-79-1
• Molecular Formula: C₁₆H₂₄N₂O₂
• Molecular Weight: 276.37
• Product Categories: pharmacetical
• Mol File: 875798-79-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 412.737°C at 760 mmHg
• Flash Point: 203.417°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.96±0.10(Predicted)
• CAS DataBase Reference: 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(875798-79-1)
• EPA Substance Registry System: 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(875798-79-1)

Safety Data

• Hazardous Substances Data: 875798-79-1(Hazardous Substances Data)

Usage

General Description

3-(4-amino-phenyl)-piperidine-1-carboxylic acid tert-butyl ester is a chemical compound with the molecular formula C16H24N2O2. It is a tertiary amine derivative that is commonly used in the field of organic synthesis and pharmaceutical research. 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is a piperidine-based building block that can be utilized for the construction of various complex molecules. Its tert-butyl ester functional group provides stability and protection for the carboxylic acid moiety, making it a valuable intermediate in the synthesis of pharmaceuticals and other biologically active compounds. Additionally, its amino-phenyl group makes it a potential precursor for the development of new drug candidates targeting specific molecular pathways.

InChI:InChI=1/C16H24N2O2/c1-16(2,3)20-15(19)18-10-4-5-13(11-18)12-6-8-14(17)9-7-12/h6-9,13H,4-5,10-11,17H2,1-3H3

Upstream product

• 4282-46-6 3-(4'-nitrophenyl)pyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 636-98-6 p-nitrobenzene iodide 
• 19733-56-3 3-(4-aminophenyl)piperidine 
• 92137-91-2 3-(4-nitrophenyl)piperidine-2,6-dione 
• 19733-55-2 3-(4-nitrophenyl)piperidine 
• 19509-09-2 3-Phenylpiperidine hydrochloride 
• 586-78-7 para-nitrophenyl bromide 
• 1692-25-7 3-pyridylboronic acid 
• 34619-03-9 tert-butyldicarbonate 

Downstream Products

• 1038915-99-9 tert-butyl 3-[4-({[3-(methoxycarbonyl)-2-nitrophenyl]methylene}amino)phenyl]piperidine-1-carboxylate 
• 1171197-20-8 (3S)-3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1263284-59-8 (+)-(R)-tert-butyl 3-(4-aminophenyl)piperidine-1-carboxylate 
• 1038915-64-8 (3S)-3-[4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidinium chloride 
• 1196713-67-3 2-[4-((3S)-(tertbutoxycarbonyl)piperidin-3-yl)phenyl]-2H-indazole-7-carboxylic acid methyl ester 
• 1038916-11-8 tert-butyl (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidine-1-carboxylate 
• 1038916-08-3 2-{4-[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]phenyl}-2H-indazole-7-carboxylic acid 
• 1312106-32-3 18-(nitrobenzylideneamino)phenylpiperidine-1-carboxylate 
• 1338544-06-1 tert-butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 
• 1038915-92-2 tert-butyl 3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}-piperidine-1-carboxylate 
• 1038915-90-0 methyl 2-{4-[1-(tert-butoxycarbonyl)piperidin-3-yl]phenyl}-2H-indazole-7-carboxylate 
• 1393900-43-0 2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide 

Relevant articles and documents

PROCESSES FOR THE PREPARATION OF NIRAPARIB AND INTERMEDIATES THEREOF

The present invention relates to novel procedures and novel intermediates useful in the synthesis of Niraparib or any salt thereof.

FAK AND FLT3 INHIBITORS

The use of a compound of the formula (I): (Formula (I)) in the preparation of a medicament for treating Acute Myeloid Leukemia or a disease ameliorated by the inhibition of Flt3, or Flt3 and FAK.

Development of a fit-for-purpose large-scale synthesis of an oral PARP inhibitor

Compound (1) a poly(ADP-ribose)polymerase (PARP) inhibitor has been made by a fit-for-purpose large-scale synthesis using either a classical resolution or chiral chromatographic separation. The development and relative merits of each route are discussed,