4300-02-1Relevant articles and documents
Ester enolate Claisen rearrangement using a polymer-supported silyl triflate
Hu, Yonghang,Porco Jr., John A.
, p. 3289 - 3292 (1999)
Polystyrene-diethylsilane resin (PS-DES) was treated with triflic acid to form a highly reactive polymer silyl triflate. The silyl triflate reacted with enolizable allylic esters in the presence of Et,N to afford resin-bound silyl ketene acetals, which undergo Ireland-Claisen rearrangement at elevated temperature to provide polymer silyl esters. Transesterification of the polymeric silyl esters with 5% H2SO4 in 1:1 MeOH/ClCH2CH2Cl (DCE) afforded methyl ester products.
C?Boron Enolates Enable Palladium Catalyzed Carboboration of Internal 1,3-Enynes
Wang, Ziyong,Wu, Jason,Lamine, Walid,Li, Bo,Sotiropoulos, Jean-Marc,Chrostowska, Anna,Miqueu, Karinne,Liu, Shih-Yuan
supporting information, p. 21231 - 21236 (2021/09/02)
A new family of carbon-bound boron enolates, generated by a kinetically controlled halogen exchange between chlorocatecholborane and silylketene acetals, is described. These C?boron enolates are demonstrated to activate 1,3-enyne substrates in the presence of a Pd0/Senphos ligand complex, resulting in the first examples of a carboboration reaction of an alkyne with enolate-equivalent nucleophiles. Highly substituted dienyl boron building blocks are produced in excellent site-, regio-, and diastereoselectivity by the described catalytic cis-carboboration reaction.
GAMMA LACTAMS AS PROSTAGLANDIN AGONISTS AND USE THEREOF
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Page 101, (2010/02/05)
1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, or gastric ulcer, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.