4339-94-0

Basic information

• Product Name: Acetic acid 3-(dimethylamino)propyl ester
• Synonyms: Acetic acid 3-(dimethylamino)propyl ester
• CAS NO: 4339-94-0
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.2
• Mol File: 4339-94-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 176.5±23.0 °C(Predicted)
• Appearance: /
• Density: 0.937±0.06 g/cm3(Predicted)
• PKA: 9.30±0.28(Predicted)
• CAS DataBase Reference: Acetic acid 3-(dimethylamino)propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 3-(dimethylamino)propyl ester(4339-94-0)
• EPA Substance Registry System: Acetic acid 3-(dimethylamino)propyl ester(4339-94-0)

Safety Data

• Hazardous Substances Data: 4339-94-0(Hazardous Substances Data)

Upstream product

• 3179-63-3 3-Dimethylamino-1-propanol 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 592-33-6 3-bromopropyl acetate 
• 124-40-3 dimethyl amine 
• 2466-76-4 N-Acetylimidazole 
• 830-03-5 4-nitrophenol acetate 
• 141-78-6 ethyl acetate 

Downstream Products

• 2155-94-4 N,N-dimethyl-2-propen-1-amine 
• 79-20-9 acetic acid methyl ester 
• 6163-56-0 N,N'-dimethyl-1-propenylamine 
• 64-19-7 acetic acid 
• 124-40-3 dimethyl amine 
• 74-99-7 prop-1-yne 
• 155955-37-6 3-(N,N-dimethylamino)propyl 3-hydroxy-3-(4-nitrophenyl)propionate 
• 1026907-42-5 C₂₂H₃₅Cl₄N₄O₅P 

Relevant articles and documents

The Influence of Anchoring Substitution in 1,3-Amino Alcohols on the Rate and Mechanism of Esterification by Acetylimidazole and by p-Nitrophenyl Acetate

Enforced intramolecular hydrogen bonding in 2-tert-butyl-3-(N,N-dimethylamino)propan-1-ol is shown by the competitive alcoholysis of p-nitrophenyl acetate and 1-acetylimidazole in acetonitrile, and by the corresponding second-order rate constants and activation parameters, to influenece both the rate and the mechanism of catalysed acyl transfer.

Lipase-mediated selective acetylation of primary alcohols in ethyl acetate

An environmental friendly process to selectively acetylate primary alcohols was demonstrated. The esterification process consists of treatment of a primary alcohol in the presence of immobilized C. antarctica lipase (Novozyme-435) in ethyl acetate at room temperature. Primary alcohols were acetylated in the presence of secondary alcohols and phenols.

Mechanism of esterification of 1,3-dimethylamino alcohols by N-acetylimidazole in acetonitrile and the influence of alkyl and geminal dialkyl substitution upon the rate

3-(Dimethylamino)propan-1-ol and seven derivatives with alkyl substituents at the 2-position have been prepared by conventional methods, and second-order rate constants for their esterification by N-acetylimidazole in acetonitrile have been measured under pseudo-first-order conditions both by 1H NMR spectroscopy at a single temperature (23°C) and by a UV spectroscopic method over the temperature range 25-65°C. Evidence is presented that the intermolecular esterifications proceed via an initial rate-determining intramolecular general base catalysed formation of a cyclic tetrahedral intermediate. Effective molarities compared with the third-order reactions of simpler alcohols with acetylimidazole catalysed by triethylamine are estimated to be 13-14 mol dm-3, but alkyl substitution at the 2-position of the amino alcohol has only a modest effect upon reaction rates. All reactions have substantial negative entropies of activation and only modest enthalpies of activation as expected for concerted bimolecular reactions with highly ordered transition structures. Three structurally related carbocyclic amino alcohols constitute a short isokinetic series with the isokinetic temperature very close to the experimental range. Along this series, decreasing enthalpies of activation are almost exactly balanced in their contributions to the overall free energy of activation near room temperature by increasingly negative entropies of activation.