4376-27-6

Usage

Uses

Used in the Food Industry:
2-(biphenyl-4-yl)-2-oxoethyl acetate serves as a flavoring agent, enhancing the taste and aroma profiles of various food products, contributing to a more appealing consumer experience.
Used in the Cosmetics and Perfume Industries:
In these industries, 2-(biphenyl-4-yl)-2-oxoethyl acetate is utilized as a fragrance, adding pleasant scents to products, which can influence consumer preference and product appeal.
Used in Pharmaceutical Synthesis:
2-(biphenyl-4-yl)-2-oxoethyl acetate plays a role in the synthesis of pharmaceuticals, acting as a building block for the development of new drugs, potentially contributing to advancements in medicinal chemistry.
Used in Organic Chemistry:
As a building block in organic chemistry, 2-(biphenyl-4-yl)-2-oxoethyl acetate is important for the creation of complex organic molecules, facilitating research and development in the field of organic synthesis.
It is crucial to handle 2-(biphenyl-4-yl)-2-oxoethyl acetate with care, adhering to safety guidelines to mitigate any health risks associated with improper handling or excessive exposure.

Upstream product

• 64-19-7 acetic acid 
• 135-73-9 2-Bromo-4'-phenylacetophenone 
• 56956-34-4 Hepta-2,4-diynyl-trimethyl-ammonium; iodide 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 218903-49-2 N-(1-([1,1'-biphenyl]-4-yl)vinyl)acetamide 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 3218-36-8 4-Phenylbenzaldehyde 
• 92-91-1 biphenyl-4-acetaldehyde 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 127-09-3 sodium acetate 
• 127-08-2 potassium acetate 
• 61668-23-3 2-diazo-1-biphenyl-4-yl-ethanone 
• 92-52-4 biphenyl 

Downstream Products

• 7496-43-7 [1,1'-biphenyl]-4-yl(4-([1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)methanone 

Relevant academic research and scientific papers

MACROLIDE BIOSYNTHESIS-II ORIGIN OF THE CARBON SKELETON AND OXYGEN ATOMS OF THE ERYTHROMYCINS

Feeding of propionate to cultures of Streptomyces erythreus gave erythromycin A and B labeled at C-1, 3, 5, 7, 9, 11 and 13, as established by (13)C NMR analysis of the derived 2'-benzoate esters.Incorporation of propionate labled C-2, 4, 6, 8, 10, 12, and 20 while feeding of ethylsuccinate, an in vivo precursor of methylmalonate, gave rise to seven pairs of enhanced and coupled doublets in the spectra of labeled erythromycin A and B benzoate.Subsequent incorporation of propionate and (13)C NMR analysis established the presence of excess (18)O at C-1, 3, 5, 9, 11, and 13 in both erythromycins A and B, as evidenced by the corresponding isotopically shifted (13)C(18)O peaks.These results establish that in the biosynthesis of erythromycin all the O atoms of the initial aglycone, 6-deoxyerythronolide B (3) originate directly from propionate.

2-Alkyl-4-arylimidazoles: Structurally novel sodium channel modulators

A series of 2-alkyl-4-arylimidazoles were prepared and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to highly potent Na+ channel blockers.

PhI(OAc)2-promoted umpolung acetoxylation of enamides for the synthesis of α-acetoxy ketones

Umpolung is a fundamental concept in organic chemistry, which provides an alternative strategy for the synthesis of target compounds which were not easily accessible by conventional methods. Herein, a mild and efficient PhI(OAc)2-promoted umpolung acetoxylation reactions of enamides was developed for the synthesis of α-acetoxy ketones. The reaction tolerates a wide range of functional groups and affords α-acetoxy ketones in good to excellent yields. PhI(OAc)2 serves as a source of acetoxy in the reaction.

Novel and efficient transformation of enamides into α-acyloxy ketones via an acyl intramolecular migration process

Hydrogen peroxide and anhydride mediated transformation of enamides to afford substituted α-acyloxy ketones is described. This transition-metal-free cascade reaction has a broad substrate scope and high efficiency. The acyl intramolecular migration procedure successfully achieved this acyloxylation process under mild conditions and increased the atom efficiency.

Silver acetate mediated acetoxylations of alkyl halides

Silver acetate promotes the acetoxylation of alkyl halides under neutral reaction conditions. The reaction is applicable to primary and activated secondary alkyl halides, and 2,2-dibromoacetophenones for preparing the corresponding acetates in good yields. The presence of ester, amide, nitrile, hydroxy, and OTBDMS functions on the substrate is tolerated.

Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists

Leukocyte recruitment of sites of inflammation and tissue injury involves leukocyte rolling along the endothelial wall, followed by firm adherence of the leukocyte, and finally transmigration of the leukocyte across cell junctions into the underlying tissue. The initial rolling step is mediated by the interaction of leukocyte glycoproteins containing active moieties such as sialyl Lewisx (sLex) with P-selectin expressed on endothelial cells. Consequently, inhibition of this interaction by means of a small molecule P-selectin antagonist is an attractive strategy for the treatment of inflammatory diseases such as arthritis. High-throughput screening of the Wyeth chemical library identified the quinoline salicylic acid class of compounds (1) as antagonists of P-selectin, with potency in in vitro and cell-based assays far superior to that of sLex. Through iterative medicinal chemistry, we identified analogues with improved P-selectin activity, decreased inhibition of dihydrooratate dehydrogenase, and acceptable CYP profiles. Lead compound 36 was efficacious in the rat AIA model of rheumatoid arthritis.

An efficient method for the α-acetoxylation of ketones

α-Acetoxylation of ketones catalyzed by iodobenzene using 30% aqueous hydrogen peroxide and acetic anhydride as the oxidant is an effective and economical method for the preparation of a-acetoxy ketones. The reaction gave the products in good yields witho

Conversion of Aldehydes to α-Acetoxymethyl Ketones: One-carbon Homologation with (Benzotriazol-1-yl)phenoxymethane

Reaction of aldehydes with (benzotriazol-1-yl)phenoxymethyl anion afforded the corresponding addition products which, upon treatment with p-toluenesulfonic acid in acetic acid, yielded the corresponding α-acetoxymethylketones.