439153-64-7Relevant academic research and scientific papers
Streamlined processes for the synthesis of a farnesyl transferase inhibitor drug candidate
Andresen, Brian M.,Couturier, Michel,Cronin, Brian,D'Occhio, Michael,Ewing, Marcus D.,Guinn, Mark,Hawkins, Joel M.,Jasys, V. John,LaGreca, Susan D.,Lyssikatos, Joseph P.,Moraski, Garrett,Ng, Karl,Raggon, Jeffrey W.,Stewart, A. Morgan,Tickner, Derek L.,Tucker, John L.,Urban, Frank J.,Vazquez, Enrique,Wei, Lulin
, p. 643 - 650 (2013/09/02)
As part of a fast-paced oncology program, quinolinone 1 was discovered and developed as a potent inhibitor of farnesyl transferase for the treatment of cancer. The initial synthesis, which suffered from a lengthy linear sequence and a late-stage chromatog
Crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1H-quinolin-2-one, 2,3-dihydroxybutanedioate salts and method of production
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, (2008/06/13)
The invention relates to crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1H-quinolin-2-one, 2,3-dihydroxy butanedioate salts having the formula shown below: and to pharmaceutical compositions
Alkynyl-substituted quinolin-2-one derivatives useful as anticancer agents
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, (2008/06/13)
The present invention relates to compounds of formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are as defined herein. The above compounds of formula 1 are useful in
