501421-82-5Relevant academic research and scientific papers
Streamlined processes for the synthesis of a farnesyl transferase inhibitor drug candidate
Andresen, Brian M.,Couturier, Michel,Cronin, Brian,D'Occhio, Michael,Ewing, Marcus D.,Guinn, Mark,Hawkins, Joel M.,Jasys, V. John,LaGreca, Susan D.,Lyssikatos, Joseph P.,Moraski, Garrett,Ng, Karl,Raggon, Jeffrey W.,Stewart, A. Morgan,Tickner, Derek L.,Tucker, John L.,Urban, Frank J.,Vazquez, Enrique,Wei, Lulin
, p. 643 - 650 (2013/09/02)
As part of a fast-paced oncology program, quinolinone 1 was discovered and developed as a potent inhibitor of farnesyl transferase for the treatment of cancer. The initial synthesis, which suffered from a lengthy linear sequence and a late-stage chromatog
