4403-24-1

Usage

Uses

Used in Cosmetic Industry:
(3E,5E)-2-oxo-6-phenylhexa-3,5-dienoic acid is used as a pigment-regulating agent for its ability to influence melanin production, which can help in developing products that address pigmentation issues and enhance the appearance of the skin.
Used in Pharmaceutical Industry:
(3E,5E)-2-oxo-6-phenylhexa-3,5-dienoic acid is used as a potential treatment for skin conditions such as vitiligo and melanoma, due to its role in melanin biosynthesis and its potential antioxidant and UV radiation protective properties.
Used in Antioxidant Formulations:
(3E,5E)-2-oxo-6-phenylhexa-3,5-dienoic acid is used as an antioxidant in various formulations to protect against UV radiation damage, which can be beneficial in skincare products to maintain skin health and prevent premature aging.

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 127-17-3 2-oxo-propionic acid 
• 104-55-2 3-phenyl-propenal 
• 140694-54-8 (3E,5E)-(R)-2-Hydroxy-6-phenyl-hexa-3,5-dienoic acid 
• 7647-01-0 hydrogenchloride 
• 113-24-6 sodium pyruvate 
• 100-52-7 benzaldehyde 

Downstream Products

• 134478-20-9 (3E,5E)-2-[(4-Methyl-phthalazin-1-yl)-hydrazono]-6-phenyl-hexa-3,5-dienoic acid 
• 88186-48-5 C₂₀H₁₉N₃O₂S 
• 140694-54-8 (3E,5E)-(R)-2-Hydroxy-6-phenyl-hexa-3,5-dienoic acid 
• 88186-46-3 C₂₀H₁₉N₃O₂S 
• 689267-78-5 (3E,5E)-2-Oxo-6-phenyl-hexa-3,5-dienoic acid isopropyl ester 
• 939810-29-4 2-oxo-6-phenyl-hexa-3,5-dienoic acid benzyl ester 
• 1620650-59-0 C₁₂H₉ClO₂ 
• 1620650-70-5 (3E,5E)-2,2,4,4-tetramethylpentan-3-yl 2-oxo-6-phenylhexa-3,5-dienoate 
• 83451-40-5 2-Styrylthieno<2,3-b>quinoxaline 
• 134478-25-4 9-Methyl-2-((1E,3E)-4-phenyl-buta-1,3-dienyl)-3,4,10,10a-tetraaza-phenanthren-1-one 
• 689267-93-4 isopropyl (3E,5E)-2-hydroxy-6-phenylhexa-3,5-dienoate 

Relevant academic research and scientific papers

Preparation of optically pure (3E,5E)-alkyl-2-hydroxy-6-arylhexa-3,5-dienoates by Candida parapsilosis ATCC 7330 mediated deracemisation of the racemates

Biocatalytic deracemisation of a range of racemic (3E,5E)-alkyl-2-hydroxy-6-arylhexa-3,5-dienoates using Candida parapsilosis ATCC 7330 resulted in pure (S)-enantiomers in yields of up to 80% and ee>99%.

Polyfunctional (R)-2-Hydroxycarboxylic Acids by Reduction of 2-Oxo Acids with Hydrogen Gas or Formate and Resting Cells of Proteus vulgaris

Various (R)-2-hydroxy acids such as (R)-2-hydroxy-3-enoic-, 3,5-dienoic-, 4-oxo-, (R,S)-3-hydroxy and some others were prepared on a scale up to 0.12 mol by biocatalytic reduction of the corresponding 2-oxo acids with P. vulgaris and hydrogen gas and/or formate as electron donors.With the exception of the 2-hydroxy-4-oxo acids it could be proved that the enantiomeric excess is >97 percent.For the 4-oxo derivatives this enantiomeric excess can be assumed.The yields of isolated products are high because they were isolated from rather small amounts of biocatalyst and low buffer concentrations.Product concentrations in the range of 0.1- 0.24 M were obtained.For 1 mmol of product formation in 15-20 h about 20-40 mg (dry weight) of P. vulgaris cells are necessary.