4450-39-9

Upstream product

• 64-17-5 ethanol 
• 5264-33-5 5-cyanopentanoic acid 
• 14660-52-7 ethyl 5-bromovalerate 
• 143-33-9 sodium cyanide 
• 1190-69-8 adipic acid ethyl ester-amide 
• 2323-81-1 ethyl 5-chloropentanoate 
• 1122-84-5 1-ethoxycyclohexene 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 129422-07-7 ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pentanoate 
• 63972-18-9 2-(3-cyanopropyl)malonic acid diethyl ester 
• 773837-37-9 sodium cyanide 
• 2067-33-6 5-bromopentanoic acid 
• 539-74-2 Ethyl 3-bromopropionate 

Downstream Products

• 105-60-2 caprolactam 
• 1427203-28-8 N-(benzyloxy)-5-cyano-N-methylpentanamide 
• 1427203-31-3 N-(benzyloxy)-5-(1H-tetrazol-5-yl)pentanamide? 
• 1427203-32-4 N-(benzyloxy)-N-methyl-5-(1H-tetrazol-5-yl)pentanamide? 
• 1427203-25-5 N-(benzyloxy)-5-cyanopentanamide 
• 652-11-9 4,5,6,7-tetrafluorophthalimide 
• 626-86-8 adipinic acid monoethyl ester 
• 60-32-2 6-aminohexanoic acid 

Relevant academic research and scientific papers

Deboronative cyanation of potassium alkyltrifluoroborates: Via photoredox catalysis

A photoredox catalytic method was developed for the direct cyanation of alkyltrifluoroborates. This reaction provides a new and useful transformation of the easily available alkyltrifluoroborates. The photocatalytic reaction can tolerate a variety of functional groups with mild reaction conditions. Mechanistic investigations are consistent with the present reaction following a radical pathway.

Microwave-assisted aqueous Krapcho decarboxylation

The Krapcho decarboxylation of alkyl malonate derivatives has been adapted to aqueous microwave conditions. Various salt additives were examined, and both the cation and the anion impacted the facility of the reaction. A strong correlation was found between the pKa of the anion and the reaction rate, suggesting a straightforward base-catalyzed hydrolysis. Lithium sulfate gave the best results, obviating the need for DMSO co-solvent. Georg Thieme Verlag Stuttgart · New York.

Synthesis of tetrazole analogues of phosphonohydroxamic acids: An attempt to improve the inhibitory activity against the DXR

This work is focused on the design of new antimicrobial drugs and on the development of lipophilic inhibitors of the DXR, the second enzyme of the MEP pathway for the biosynthesis of isoprene units in most bacteria, by replacing the phosphonate group of fosmidomycin derivatives by a tetrazoyl moiety capable of multiple hydrogen bonding. The N- and C-substituted tetrazole analogues of phosphonohydroxamate inhibitors were synthesized and tested on the DXR of Escherichia coli. This work points out the hypothesis that the phosphonate/phosphate recognition site might be too rigid to accommodate other functional groups.

Cleavage of β-ketoesters via iminyl radicals - Application in the synthesis of a spirolactone

Reaction of Oximebenzoates of several β-ketoesters with tributyltin hydride show β-cleavage via an iminyl radical and application of this results in the synthesis of a spirolactone.

FUNCTIONAL GROUP-TOLERANT HYDROALKYLATION OF ELECTRON-DEFICIENT OLEFINS THROUGH COPPER(I)-CATALYZED PHOTOADDITION OF ORGANIC HALIDES FOLLOWED BY REDUCTION WITH ZINC

A method of accomplishing hydroalkylation of electron-deficient olefins which tolerates a variety of functional groups, in which organic halides and electron-deficient olefins are subjected to a photoreaction catalyzed by the CuBr-Bun3P complex followed by treatment with Zn dust in the presence of AcOH, has been developed.

Generation of β-Carbonyl Radicals from Cyclopropanol Derivatives by the Oxidation with Manganese(III) 2-Pyridinecarboxylate and Their Reactions with Electron-Rich and -Deficient Olefins

Various β-carbonyl radicals are generated oxidatively from cyclopropanol derivatives by the use of manganese(III) 2-pyridinecarboxylate (Mn(pic)3).These β-carbonyl radicals react with electron-rich olefins such as conjugated silyl enol ethers, a ketene th

HYDROLYSIS IN THE ABSENCE OF BULK WATER 2. CHEMOSELECTIVE HYDROLYSIS OF NITRILES USING TETRAHALOPHTHALIC ACIDS

The reaction of nitriles with tetrafluorophthalic or tetrachlorophthalic acid gives carboxylic acids in good yield.The reaction is chemoselective in that the nitrile functionality can be hydrolyzed in the presence of ester groups.

Synthesis of some monothienylalkyl esters of aliphatic dicarboxylic acids

1. A. new method was developed for the synthesis of the half-esters of dicarboxylic acids. 2. Some members of the acid esters of acidophobic alcohols were synthesized, and specifically the mono-3-(2-thienyl)propyl ester of adipic acid and the mono-2-(2-thienyl)ethyl ester of pimelic acid.