4481-57-6

Upstream product

• 3003-84-7 Tetrahydrofurfuryl chloride 
• 62-53-3 aniline 
• 97-99-4 Tetrahydrofurfuryl alcohol 
• 98-01-1 furfural 
• 4795-29-3 TETRAHYDROFURFURYLAMINE 
• 108-86-1 bromobenzene 
• 98-80-6 phenylboronic acid 
• 1191-99-7 2,3-dihydro-2H-furan 
• 201230-82-2 carbon monoxide 
• 4439-56-9 N-(furan-2-ylmethyl)aniline 
• 100-62-9 N-methylenebenzenamine 
• 109-99-9 tetrahydrofuran 
• 100-61-8 N-methylaniline 

Downstream Products

• 145759-94-0 5-(3-chloropropyl)-3-phenyl-2-oxazolidinone 

Relevant academic research and scientific papers

Synthesis of a hybrid Pd0/Pd-carbide/carbon catalyst material with high selectivity for hydrogenation reactions

We present a highly selective and active Pd carbon catalyst prepared by an easy hydrothermal synthesis method. This synthetic procedure allows the stabilization under mild conditions of interstitial carbon atoms on the surface of a Pd0 carbon catalyst. The so formed Pd carbide phase appears on the upper surface layers of the Pd carbon catalyst, as demonstrated by X-ray photoelectron depth profile analysis using variable synchrotron X-ray energies. The presence of carbon in the palladium carbide species modifies the electronic state of surface Pd atoms, resulting in more electron positive Pd species (Pdδ+). This influences the adsorption of reactants and reaction intermediates during the hydrogenation of alkynes, dienes and imines, resulting in high selectivities at practically 100percent conversion.

Conversion of furfural to tetrahydrofuran-derived secondary amines under mild conditions

The production of amino-containing compounds from biomass is an important goal of research programs. Starting from carbohydrate-based furfural, a simple and highly efficient system was developed for producing a library of secondary and tertiary tetrahydrofurfurylamines under mild conditions (25 °C/1 bar H2) with excellent yields (>90%). Commercially available Pd/Al2O3 proved to be a suitable catalyst and exhibited outstanding performance.

USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND COMPOSITIONS COMPRISING SUCH ACTIVE INGREDIENTS

The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.

Highly Efficient and Selective N-Alkylation of Amines with Alcohols Catalyzed by in Situ Rehydrated Titanium Hydroxide

Catalytic N-alkylation of amines by alcohols to produce desired amines is an important catalytic reaction in industry. Various noble-metal-based homogeneous and heterogeneous catalysts have been reported for this process. The development of cheap non-noble-metal heterogeneous catalysts for the N-alkylation reaction would be highly desirable. Hereby, we propose the N-alkylation of amines by alcohols over a cheap and efficient heterogeneous catalyst-titanium hydroxide. This catalyst provides a selectivity higher than 90% to secondary amines for functionalized aromatic and aliphatic alcohols and amines with high catalytic activity and stability. Mild Br?nsted acidity formed by the continuous rehydration of Lewis acidity excludes the side reactions and deactivation by adsorbed species. The mechanism of the reaction involves dehydration of alcohols to ethers with subsequent C-O bond cleavage by amine with the formation of secondary amine and recovery of alcohol.

Iron-Catalyzed Regioselective α-C-H Alkylation of N-Methylanilines: Cross-Dehydrogenative Coupling between Unactivated C(sp3)-H and C(sp3)-H Bonds via a Radical Process

The iron-catalyzed α-C-H alkylation of N-methylanilines without any directing group by cross-dehydrogenative coupling between unactivated C(sp3)-H and C(sp3)-H bonds has been established for the first time, which provides a good complement to C(sp3)-H activation reactions and expands the field of Fe-catalyzed C-H functionalizations. Many different C(sp3)-H bonds in cyclic alkanes, cyclic ethers, and toluene derivatives can be used as coupling partners. Mechanistic investigations including the radical reaction process, the main role of various reagents, and the kinetic isotope effect experiment were also described.

One-Pot Synthesis of N-Arylated Amines by Hydroaminomethylation of 2,5-Dihydrofuran with Aromatic Amines

A new efficient catalytic system for one-step synthesis of N-arylated amines, for example, an important intermediate, 4-ethyl- N -[(tetrahydrofuran-3-yl)methyl]aniline, is achieved by using different rhodium precursor and phosphorus ligands catalyzed hydr

Ligand- and Base-Free Copper(II)-Catalyzed C-N Bond Formation: Cross-Coupling Reactions of Organoboron Compounds with Aliphatic Amines and Anilines

(Equation presented) A ligandless and base-free Cu-catalyzed protocol for the cross-coupling of arylboronic acids and potassium aryltrifluoroborate salts with primary and secondary aliphatic amines and anilines is described. The process utilizes catalytic copper(II) acetate monohydrate and 4 A molecular sieves in dichloromethane at slightly elevated temperatures under an atmosphere of oxygen. A broad range of functional groups are tolerated on both of the cross-coupling partners.

A fully integrated high-throughput screening methodology for the discovery of new polyolefin catalysts: Discovery of a new class of high temperature single-site group (IV) copolymerization catalysts

For the first time, new catalysts for olefin polymerization have been discovered through the application of fully integrated high-throughput primary and secondary screening techniques supported by rapid polymer characterization methods. Microscale 1-octene primary screening polymerization experiments combining arrays of ligands with reactive metal complexes M(CH2Ph)4 (M = Zr, Hf) and multiple activation conditions represent a new high-throughput technique for discovering novel group (IV) polymerization catalysts. The primary screening methods described here have been validated using a commercially relevant polyolefin catalyst, and implemented rapidly to discover the new amide-ether based hafnium catalyst [η2- (N,O)-(2-MeO-C6H4) (2,4,6-Me3C6H2)N]Hf (CH2Ph)3 (1), which is capable of polymerizing 1-octene to high conversion. The molecular structure of 1 has been determined by X-ray diffraction. Larger scale secondary screening experiments performed on a focused 96-member amine-ether library demonstrated the versatile high temperature ethylene-1-octene copolymerization capabilities of this catalyst class, and led to significant performance improvements over the initial primary screening discovery. Conventional one gallon batch reactor copolymerizations performed using selected amide-ether hafnium compounds confirmed the performance features of this new catalyst class, serving to fully validate the experimental results from the high-throughput approaches described herein.

HYDROGENATION AMINATION OF FURFURAL BY AROMATIC AMINES ON PALLADIUM CATALYSTS

The hydrogenation amination of furfural by aromatic amines under mild conditions (H2 pressure 0.1 MPa, t=20-60 deg C, organic solvents on Pd/C and on palladium-containing anionites AN-1 and AV-17-8) proceeds via the formation of the corresponding azomethines with their subsequent hydrogenation to N-tetrahydrofurfurylaromatic amines.The yield of the latter as a function of the nature of the aminating agent varies from 4 to 100percent.The rate of the reaction on AN-1 and Pd/C decreases linearly with an increasing Hammett constant of the substituent in the aromatic ring of the aminating agent, while on AV-17-8-Pd it decreases linearly with an increasing absolute magnitude of the Hammett constant.For all the catalysts a linear relationship between the rate of the reaction and the dielectric permeability of the solvent was found.