44826-45-1Relevant articles and documents
Catalytic oxidation of alkanethiols and dialkyldisulfides to alkanesulfonic acids by H2O2/CH3ReO3 examined by electrospray ionization mass spectrometry
Murphy, Austin B.,Duong, Chi N.,Crenshaw, Karmalita K.,Hartman, Savannah K.,Barrett, William F.,Whitehead, Alyssa R.,Lampkins, Andrew J.,Gregory, Brian W.
, p. 241 - 247 (2014/04/03)
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Thiamin Biosynthesis in Saccharomyces cerevisiae: Origin of the Pyrimidine Unit
Grue-Sorensen, Gunnar,White, Robert L.,Spenser, Ian D.
, p. 146 - 158 (2007/10/02)
Radioactivity from 14C>formate, from D-14C>-, D-14C>-, and D-3H,6-14C>glucose, from D-14C>fructose and from 14C>- and 14C>glycerol is incorporated nonrandomly into the pyrimidine moiety of thiamin in Saccharomyces cerevisiae.The observed incorporation pattern, established by a new chemical degradation, leads to the inference that there are two biosynthetic pathways to the pyrimidine moiety of thiamin in yeast.In the major pathway, formate is the precursor of C-4 of the pyrimidine nucleus, while hexose metabolites serve as the source of the remaining five carbon atoms of the pyrimidine unit.In the minor pathway, it is C-2 and not C-4 of the pyrimidine nucleus which is derived from formate, while C-4,-5 orginates from carbohydrate.The source of C-2', C-5', and C-6 of the pyrimidine unit in this minor pathway remains unknown.Activity from 14C>citrulline and 14C>urea is not incorporated into thiamin.
