457-77-2

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 371-40-4 4-fluoroaniline 
• 52162-36-4 C₉H₉F₂NO 
• 404-47-7 (4-fluoro-phenyl)-thiocarbamic acid O-ethyl ester 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 350-46-9 4-Fluoronitrobenzene 
• 101-99-5 N-carboethoxyaniline 
• 1195-45-5 para-fluorophenyl isocyanate 
• 124-38-9 carbon dioxide 
• 75-03-6 ethyl iodide 

Downstream Products

• 145858-61-3 5-tert-Butyl-3-(4-fluoro-phenyl)-3H-oxazol-2-one 
• 1356965-19-9 2-[(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(4-fluorophenyl)hydrazinecarboxamide 
• 1356965-27-9 (5RS)-5-(benzo[d][1,3]dioxol-5-yl)-3-tert-butyl-N-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide 
• 153885-60-0 N-(4-fluorophenyl)hydrazinecarboxamide 
• 130409-77-7 2,4,6-trifluorophenylurethane 
• 2145-87-1 N-(2.4-Difluor-phenyl)-carbamidsaeureethylester 

Relevant academic research and scientific papers

Chemoselective synthesis of carbamates using CO2 as carbon source

Synthesis of carbamates directly from amines using CO2 as the carbon source is a straightforward and sustainable approach. Herein, we describe a highly effective and chemoselective methodology for the synthesis of carbamates at room temperature and atmosp

Design and synthesis of novel stiripentol analogues as potential anticonvulsants

A series of stiripentol (STP) analogues namely, 2-[(1E)-1-(1,3-benzodioxol- 5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(aryl/H)hydrazinecarboxamides 7a-h, (±)-(5RS)-N-(aryl/H)-(1,3-benzodioxol-5-yl)-3-tert-butyl-4, 5-dihydro-1H-pyrazole-1-carboxamides (±)-8a-h, and (±)-[(5RS)-(1, 3-benzodioxol-5-yl)-3-tert-butyl-4,5-dihydro-1H-pyrazol-1-yl](aryl)methanones (±)-13a-f was synthesized by adopting appropriate synthetic routes and was pharmacologically evaluated in the preliminary anticonvulsant screens. The selected bioactive new chemical entities were subjected to ED50 determination and neurotoxicity evaluation. The most active congeners are 7h in MES screen and (±)-13b in scPTZ screen which displayed ED50 values of 87 and 110 mg/kg, respectively, as compared to that of STP (ED 50 = 277.7 and 115 mg/kg in MES and scPTZ, respectively).

Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones

The synthesis and antibacterial activity of several new 5-((3-oxoisothiazol-2(3H)-yl)methyl)-3-phenyloxazolidin-2-ones 8 and analogous 2-(4-substituted phenyl)-3(2H)-isothiazolones 3 and 4 substituted at 4 and/or 3-positions of the phenyl moiety with different groups of which some have shown to increase the antibacterial activity of both 3-aryl-2-oxazolidinones and 3(2H)-isothiazolones is described. The most active compounds were isothiazolyl oxazolidinones 8a,j with unsubstituted and 8b with 4-F substituted phenyl rings which showed activities higher than analogous 3(2H)-isothiazolones and comparable or superior to linezolid, vancomycin, and ciprofloxacin against some tested microorganisms. The change in position of F and/or the use of larger substituents gave compounds with reduced or no activity. Evaluation of cytotoxicity to mouse fibroblast (NIH/3T3) cells indicated that these compounds exhibit antibacterial activity at non-cytotoxic concentrations.

Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions

The preparation and use of an azide-containing monolithic reactor is described for use in a flow chemistry device and in particular for conducting Curtius rearrangement reactions via acid chloride inputs. The Royal Society of Chemistry 2008.

Synthesis of some heterocycle containing urea derivatives and their anti-viral activity

Some new isoindol heterocyclic ureas (6a-6i) have been synthesized using N-aminophthalimide (2) and ethyl N-monosubstituted/ethyl N,N-disubstituted carbamate (5a-5i). All the newly synthesized final compounds have been evaluated for their anti-viral activities against a variety of viruses. The compound (6f) with the methoxy substituent showed reasonably better activity as compared to the standard drugs against all the viruses (cf. Tables 1, 2 and 3). Further, all the products (6a-6i) were found to be active against Vesicular stomatitis virus, Coxsackie virus B4 and Respiratory syncytical virus (cf. Table 2) and the compounds (6h) and (6i) displayed better antiviral activity in comparison to Brivudin and (S)-DHPA (cf. Table 3).

1-Fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate): An electrophilic fluorinating agent

1-Fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), NFTh, is a electrophilic fluorinating that can be used to fluorinate aromatic rings, olefins, dienol acetates and enol ethers. When NFTh is reacted with an active methylene compound in the presence of ZnCl2, the corresponding mono- or di-fluoro derivative can be isolated.

Zinc promoted simple and convenient synthesis of carbamates: An easy access for amino group protection

Synthesis of alkyl, aryl, heterocyclic, carbohydrate and amino acid carbamates is described. The protection of the amino group in the presence of other functionality in amino acids demonstrates the importance of this method.

Method for treating swine dysentery with the derivatives of the antibiotic A82810

New polyether antibiotic A82810, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A82810 by culture of Actinomodura fibrosa sp. nov. NRRL 18348 and synergistic compositions of the A82810 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.

Kinetics of the Mercury(II) Ion-promoted Desulfurisation of Thiocarbamates in Aqueous Solution

In a 1percent dioxane-water solvent in the presence of Hg2+ ions thiocarbamates p-RC6H4NHC(S)OEt (R = MeO, Me, H, F) rapidly form complexes of 2 thiocarbamate: 1 Hg2+ stoichiometry.In the presence of an excess of Hg2+ ions partial conversion to the 2:2-complexes probably occurs which decompose to the corresponding carbamates (p-RC6H4NHCO2Et) and HgS.With R = NO2 the 2:2 complex is dominant even at low Hg2+ ion concentrations, and desulfurisation is then independent of 2+>.Electron-withdrawal by R favours the 2:2 complex but decreases its rate of decomposition to products.The effects of changes in the hydrogen ion concentration suggest that ionisation of N-bound protons in the complexes favours reaction.A mechanism is suggested.The kinetic behaviour is somewhat similar to that found previously for thiobenzamides, but the new results suggest the mechanism previously proposed may need revision.