458-76-4

Basic information

• Product Name: 1,2-BIS(4-FLUOROPHENYL)ETHANE
• Synonyms: 1,2-BIS(4-FLUOROPHENYL)ETHANE;1,2-Bis(4-fluorophenyl)ethane 97%;1,2-Bis(4-fluorophenyl)ethane97%
• CAS NO: 458-76-4
• Molecular Formula: C₁₄H₁₂F₂
• Molecular Weight: 218.24
• Mol File: 458-76-4.mol
• Article Data: 37

Chemical Properties

• Melting Point: 90
• Boiling Point: 269
• Flash Point: 96.3 °C
• Appearance: /
• Density: 1.14 g/cm³
• CAS DataBase Reference: 1,2-BIS(4-FLUOROPHENYL)ETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-BIS(4-FLUOROPHENYL)ETHANE(458-76-4)
• EPA Substance Registry System: 1,2-BIS(4-FLUOROPHENYL)ETHANE(458-76-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 458-76-4(Hazardous Substances Data)

Usage

General Description

1,2-Bis(4-fluorophenyl)ethane is a chemical compound with the molecular formula C14H12F2. It is a colorless crystalline solid that is insoluble in water. 1,2-Bis(4-fluorophenyl)ethane is used as a building block in organic synthesis and is commonly employed in the production of pharmaceuticals, agrochemicals, and dyes. It possesses two fluorine-substituted phenyl groups attached to an ethane backbone, making it a valuable intermediate in the development of various organic compounds. Additionally, 1,2-Bis(4-fluorophenyl)ethane has potential applications in the field of material science and has been the subject of research for its potential use in polymers and other materials. Despite its numerous potential uses, caution should be exercised when handling this compound due to its hazardous nature, as it can cause irritation to the skin, eyes, and respiratory system upon exposure.

Upstream product

• 352-32-9 p-fluorotoluene 
• 462-06-6 fluorobenzene 
• 107-06-2 1,2-dichloro-ethane 
• 3029-30-9 naphthalene-1,4-dicarbonitrile 
• 53458-16-5 1,2-bis(4-fluorophenyl)-2-hydroxyethan-1-one 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 75-65-0 tert-butyl alcohol 
• 588-56-7 (Z)-1,2-bis(4-fluorophenyl)ethylene 
• 588-56-7 (E)-1,2-di(4-fluorophenyl)ethene 
• 459-46-1 4-Fluorobenzyl bromide 
• 100-52-7 benzaldehyde 
• 7446-70-0 aluminium trichloride 
• 1078-58-6 diphenylzinc 
• 74-85-1 ethene 

Downstream Products

• 81557-40-6 C₃₆H₂₂F₄N₄ 

Relevant articles and documents

Reactions of benzyltriphenylphosphonium salts under photoredox catalysis

The development of benzyltriphenylphosphonium salts as alkyl radical precursors using photoredox catalysis is described. Depending on substituents, the benzylic radicals may couple to form C-C bonds or abstract a hydrogen atom to form C-H bonds. A natural product, brittonin A, was also synthesized using this method.

Synthesis of Dibenzyls by Nickel-Catalyzed Homocoupling of Benzyl Alcohols

Dibenzyls are essential building blocks that are widely used in organic synthesis, and they are typically prepared by the homocoupling of halides, organometallics, and ethers. Herein, we report an approach to this class of compounds using alcohols, which are more stable and readily available. The reaction proceeds via nickel-catalyzed and dimethyl oxalate assisted dynamic kinetic homocoupling of benzyl alcohols. Both primary and secondary alcohols are tolerated.

Aryl dechlorination and defluorination with an organic super-photoreductant

Direct excitation of the commercially available super-electron donor tetrakis(dimethylamino)ethylene (TDAE) with light-emitting diodes at 440 or 390 nm provides a stoichiometric reductant that is able to reduce aryl chlorides and fluorides. The method is very simple and requires only TDAE, substrate, and solvent at room temperature. The photoactive excited state of TDAE has a lifetime of 17.3 ns in cyclohexane at room temperature and an oxidation potential of ca. -3.4 V vs. SCE. This makes TDAE one of the strongest photoreductants able to operate on the basis of single excitation with visible photons. Direct substrate activation occurs in benzene, but acetone is reduced by photoexcited TDAE and substrate reduction takes place by a previously unexplored solvent radical anion mechanism. Our work shows that solvent can have a leveling effect on the photochemically available redox power, reminiscent of the pH-leveling effect that solvent has in acid-base chemistry.