4653-13-8

Basic information

• Product Name: 4-NAPHTHALEN-1-YL-4-OXO-BUTYRIC ACID
• Synonyms: 4-NAPHTHALEN-1-YL-4-OXO-BUTYRIC ACID;4-(1-NAPHTHYL)-4-OXOBUTANOIC ACID;4-(1-NAPHTHYL)-4-OXOBUTYRIC ACID;1-(3-CARBOXYPROPIONYL)NAPHTHALENE;CHEMBRDG-BB 5101824;4-keto-4-(1-naphthyl)butyric acid;4-naphthalen-1-yl-4-oxobutanoic acid;4-naphthalen-1-yl-4-oxo-butanoic acid
• CAS NO: 4653-13-8
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.24
• Product Categories: Aromatics;Intermediates
• Mol File: 4653-13-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 175℃
• Boiling Point: 459.6 °C at 760 mmHg
• Flash Point: 245.9 °C
• Appearance: /
• Density: 1.249 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.53±0.17(Predicted)
• CAS DataBase Reference: 4-NAPHTHALEN-1-YL-4-OXO-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NAPHTHALEN-1-YL-4-OXO-BUTYRIC ACID(4653-13-8)
• EPA Substance Registry System: 4-NAPHTHALEN-1-YL-4-OXO-BUTYRIC ACID(4653-13-8)

Safety Data

• Hazardous Substances Data: 4653-13-8(Hazardous Substances Data)

Usage

Uses

γ-Oxo-1-naphthalenebutanoic Acid (cas# 4653-13-8) is a compound useful in organic synthesis.

Upstream product

• 13672-43-0 4-(1-naphthyl)-4-oxobutyric acid methyl ester 
• 76469-33-5 2-chloro-1-(naphthalen-1-yl)ethan-1-one 
• 18424-76-5 dimethyl malonate sodium salt 
• 71-43-2 benzene 
• 108-30-5 succinic acid anhydride 
• 91-20-3 naphthalene 
• 941-98-0 1'-naphthacetophenone 
• 90-11-9 1-Bromonaphthalene 
• 13686-51-6 2-bromoaceto-1-naphthone 
• 7446-70-0 aluminium trichloride 
• 861330-63-4 (2-[1]naphthyl-2-oxo-ethyl)-malonic acid 
• 14794-31-1 ethyl 3-(chloroformyl)propionate 
• 1121-07-9 N-methylsuccinimide 
• 703-55-9 1-naphthylmagnesiumbromide 

Downstream Products

• 1590-22-3 4-(2-naphthyl)-4-oxobutyric acid 
• 781-74-8 4-(1-naphthyl)butanoic acid 
• 73931-66-5 ethyl 4-(naphthalen-1-yl)-4-oxobutanoate 
• 84716-37-0 2-(naphthalen-1-yl)-1H-pyrrole 
• 906560-16-5 5-naphthalen-1-yl-3H-furan-2-one 
• 141-82-2 malonic acid 
• 86-55-5 1-naphthalenecarboxylic acid 
• 180987-85-3 5-naphthalen-1-yldihydrofuran-2-one 

Relevant articles and documents

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Acylative Kinetic Resolution of Cyclic Hydroxamic Acids

Racemic cyclic hydroxamic acids bearing an aryl substituent adjacent to the hydroxyl group undergo effective acylative kinetic resolution promoted by benzotetramisole (BTM).

One-pot synthesis of tetralin derivatives from 3-benzoylpropionic acids: Indium-catalyzed hydrosilylation of ketones and carboxylic acids and intramolecular cyclization

This reducing system was composed of a small amount (1 mol%) of In(OAc)3, Me2PhSiH, and I2 that effectively catalyzed the hydrosilylation of two different carbonyl groups, a ketone and a carboxylic acid found in 3-benzoylpropionic acids, followed by a subsequent intramolecular cyclization that led to the one-pot preparation of tetralin derivatives.

Facile synthesis of 2-arylpyrroles from 4-oxo-butanoic acids and their use in the preparation of bis(pyrrolyl)methanes

A range of 3-aroyl-propionic acids have been cyclised to unsaturated lactones which, upon reduction using DIBAL-H and reaction with an ammonia source, gave 2-arylpyrroles (Ar = Ph, 1-naphthyl, o-phenoxyphenyl and 4-methyl-2-methylsulfanylphenyl) in excellent yields. Reaction of 2,6-disubstituted aroylpropanals (Ar = 2,4,6-Me3C6H2, anthracenyl and 2-Me-naphthalen-1-yl) with an ammonia source failed to generate pyrroles. The arylpyrroles react readily with ketones or aldehydes in ethanol or under eutectic mix melt conditions to give bis-(pyrrolyl)methanes in excellent isolated yields.