76469-33-5

Usage

Uses

Used in Organic Synthesis:
Ethanone, 2-chloro-1-(1-naphthalenyl)(9CI) is employed as a key intermediate in the synthesis of various organic materials. Its unique structure allows for the creation of a wide range of compounds with diverse applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, Ethanone, 2-chloro-1-(1-naphthalenyl)(9CI) is used as a building block for the development of new drugs. Its potential biological and pharmacological activities make it a promising candidate for the treatment of various diseases and conditions.
Used in Research and Development:
Due to its limited information and understanding, Ethanone, 2-chloro-1-(1-naphthalenyl)(9CI) is utilized in research and development to explore its properties, applications, and effects. This further investigation is crucial for uncovering its full potential and expanding its use in various fields.

Upstream product

• 60-29-7 diethyl ether 
• 105-39-5 chloroacetic acid ethyl ester 
• 703-55-9 1-naphthylmagnesiumbromide 
• 91-20-3 naphthalene 
• 79-04-9 chloroacetyl chloride 
• 879-18-5 naphthalene-1-carbonic acid chloride 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 826-74-4 1-vinylnaphthalene 
• 941-98-0 1'-naphthacetophenone 

Downstream Products

• 86-55-5 1-naphthalenecarboxylic acid 
• 80749-33-3 (2-methyl-1H-indol-3-yl)(naphthalen-1-yl) methanone 
• 1215004-64-0 (naphthalen-1-yl)(2-phenyl-1H-indol-3-yl)methanone 
• 941-98-0 1'-naphthacetophenone 
• 57605-95-5 1-(1-naphthyl)ethanol 
• 4653-13-8 4-(1-naphthyl)-4-oxobutanoic acid 
• 861330-63-4 (2-[1]naphthyl-2-oxo-ethyl)-malonic acid 

Relevant academic research and scientific papers

Facile Synthesis of α-Haloketones by Aerobic Oxidation of Olefins Using KX as Nonhazardous Halogen Source

An operationally simple and safe synthesis of α-haloketones using KBr and KCl as nonhazardous halogen sources is reported. It involves an iron-catalysed reaction of alkenes with KBr/KCl using O2 as terminal oxidant under the irradiation of visible-light. This strategy avoids the risks associated with handling halo-contained electrophiles (Cl2, Br2, NCS, NBS). The process is tolerant to several functional groups, and extended to a range of substituted styrenes in up to 89% yield. A radical reaction pathway is proposed based on control experiments and spectroscopy studies.

OLED electron transport material as well as preparation method and application thereof (by machine translation)

The invention belongs to the technical field of organic electronic transmission materials, and relates to OLED electron transport materials as well as a preparation method and application thereof. OLED (Organic Light Emitting Diode) electron transport material in particular relates to a small molecule OLED material with an asymmetric structure containing a benzoxazole group on one side and an aryl group with electron transport performance at one side. As the electron transport material is applied to OLED devices, good device performance and lower driving voltage can be obtained; meanwhile, the luminous efficiency and the service life of the device are greatly improved. (by machine translation)

Asymmetric transfer hydrogenation of 1-naphthyl ketones by an ansa-Ru(II) complex of a DPEN-SO2N(Me)-(CH2)2(η 6-p-tol) combined ligand

The first second-generation designer Ru(II) catalyst 1b featuring an enantiopure N,C-(N-ethylene-N-methyl-sulfamoyl)-tethered (DPEN- κ2N,N′)/η6-toluene hybrid ligand is introduced. Using an S/C = 1000 in HCO2H-Et3N 5:2 transfer hydrogenation medium, secondary 1-naphthyl alcohols are obtained in up to >99.9% ee under mild conditions. Mechanistic factors are discussed.

Catalytic diastereo- and enantioselective annulations between transient nitrosoalkenes and indoles

Caught in transition: An efficient catalytic system is the key to the successful development of the first highly diastereo- and enantioselective annulation reaction between indoles and transient nitrosoalkenes. This robust reaction affords structurally unique architectures with up to three new chiral centers. The products can be readily elaborated into other indoline-based chiral heterocyclic motifs, including those of pyrrolidinoindoline alkaloids. Copyright

Synthetic Studies on Indoles and Related Compounds. XV. An Unusual Acylation of Ethyl Indole-2-Carboxylate in the Friedel-Crafts Acylation

The Friedel-Crafts reaction of ethyl indole-2-carboxylate (1a) with acyl chlorides or acid anhydrides in the presence of Lewis acids was investigated in order to establish a preparative procedure for the corresponding ethyl 3-acylindole-2-carboxylates (4).Although monoacylation occured successfully, the products were generally a mixture of ethyl 3-, 5-, and 7-acylindole-2-carboxylates (4,5 and 6).The ratio of the yields of these three products varied greatly depending on reaction conditions and reagents used.A tendency that the 3-acylindole (4) was obtained as a main product was observed when a Lewis acid other than aluminum chloride was used as a catalyst and/or an acyl chloride derived from a weaker acid was employed, whereas a tendency for formation of the 5- and 7-acylindoles (5 and 6) was observed when aluminum chloride and/or an acyl chloride derived from a stronger acid was used.As to the 5- and 7-acylindoles (5 and 6) , the yields of the former were always much higher than those of the latter (6).The result indicates that ethyl 3- and 5-acylindole-2-carboxylates can be regioselectively prepared from a common substrate (1a) by changing the reaction conditions or reagents. friedel-craft acylation; ethyl indole-2-carboxylate; acyl chloride; acid anhydride; lewis acid; aluminum chloride; acylindole

Kinetics of ω-Chlorination of 1-Acetonaphthone by N-Chloro-3-methyl-2,6-diphenylpiperidin-4-one with and without Chloride Ions

The kinetics of chlorination of 1-acetonaphthone with N-chloro-3-methyl-2,6-diphenylpiperidin-4-one (NCP) in the absence of chloride ions and also in the presence of a sufficient excess of chloride ions have been studied.In the former case, the order with respect to is one and those with respect to and +> are fractional.In the latter case, the order with respect to and -> each is zero and that with respect to and +> each is unity.The kinetic data have been rationalised, suitable mechanisms proposed and thermodynamic parameters Ea, ΔS*, ΔH* and ΔG* have been reported for both the cases.

DIRECTION OF ACYLATION OF NAPHTHALENE BY THE FRIEDEL-CRAFTS METHOD

The Friedel-Crafts acylation of naphthalene by the halides of substituted and unsubstituted aliphatic carboxylic acids with various chain lengths (C2-C6) and various degrees of branching in the hydrocarbon chain was investigated.The effect of the solvent on the direction of acylation shows up during acylation by the least hindered acylating agents (acetyl chloride, acetyl bromide, chloroacetyl chloride, and bromoacetyl bromide).The α isomer is obtained preferentially in chloroform and the β isomer in nitrobenzene.With increase in the length and degree of branching of the hydrocarbon chain the β position of the naphthalene ring becomes the preferred direction of acylation.The main factor which determines the direction of Friedel-Crafts acylation in naphthalene is the steric factor.