4691-72-9

Upstream product

• 34559-52-9 3-(4-nitrophenyl)oxirane-2,2-dicarbonitrile 
• 64-17-5 ethanol 
• 105-36-2 ethyl bromoacetate 
• 100-00-5 4-chlorobenzonitrile 
• 3900-83-2 ethyl α-diazo-4-nitrophenylacetate 
• 5445-26-1 ETHYL 4-NITROPHENYLACETATE 
• 2700-23-4 4-Nitrobenzylidenemalononitrile 
• 617-33-4 ethyl dibromoacetate 
• 98-95-3 nitrobenzene 

Downstream Products

• 102862-29-3 3-(4-Nitro-phenyl)-imidazo[1,2-a]pyrimidin-2-ol 
• 1297493-03-8 ethyl 5-oxo-2,4-di(4-nitrophenyl)-2,5-dihydro-1H-imidazol-2-carboxylate 
• 86215-68-1 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione 
• 93579-36-3 1-(p-nitrophenyl)-cyclopropane-1,2-dicarboxylic acid 
• 93579-39-6 1-<4-(acetylamino)phenyl>-3-azabicyclo<3.1.0>hexane-2,4-dione 
• 66504-69-6 1-(4-nitrophenyl)-3-azabicyclo<3.1.0>hexane-2,4-dione 
• 1416850-47-9 5-(4-nitrophenyl)-2-(pyrazin-2-yl)thiazol-4-ol 
• 1416850-48-0 5-(4-nitrophenyl)-2-(pyrimidin-2-yl)thiazol-4-ol 
• 1416850-46-8 5-(4-nitrophenyl)-2-(pyridin-2-yl)thiazol-4-ol 
• 1376711-44-2 5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazol-4-ol 
• 1417902-08-9 2-(furan-2-yl)-5-(4-nitrophenyl)thiazol-4-ol 
• 1417902-28-3 2-(furan-2-yl)-5-(4-(2,4,6-triphenylpyridin-1-ium-1-yl)phenyl)thiazol-4-olate 
• 1417902-16-9 4-(4-(((tert-butyl)dimethylsilyl)oxy)-2-(furan-2-yl)thiazol-5-yl)aniline 
• 1417902-12-5 4-(((tert-butyl)dimethylsilyl)oxy)-2-(furan-2-yl)-5-(4-nitrophenyl)thiazole 

Relevant academic research and scientific papers

Bromination of α-Diazo Phenylacetate Derivatives Using Cobalt(II) Bromide

A method for the bromination of α-diazo phenylacetate derivatives using cobalt(II) bromide is described. This bromination reaction features a short reaction time, broad substrate scope, operational simplicity, acid-free conditions, and gram-scalability. (Figure presented.).

A one-pot preparation of 5-oxo 2,4-disubstituted 2,5-dihydro-1 H -imidazol-2-carboxylates from α-bromo esters

Nucleophilic substitution of a bromine atom by the azide group in aryl- and heteroaryl -α- bromoacetates triggers cascade reactions leading to imidazolin-5-ones formation. The α-azidoacetate intermediates undergo a transformation into non-isolable 2-imino

Practical syntheses of oxindole derivatives: Chemical development towards 2-(5-chloro-2-oxo-2,3-dihydroindol-1-yl)acetamide and (S)-2-(5-Chloro-2-oxo-2,3- dihydroindol-1-yl)propionamide

We describe development of scalable syntheses of novel oxindole-type SV2A ligands with improved potency towards seizure suppression.

Vicarious nucleophilic substitution of nitrobenzenes : Application of the reaction to 2-alkylnitrobenzenes

Vicarious nucleophilic substitution (VNS) by dichloroacetate and other reagents has been applied in good yield to various ortho-substituted nitrobenzenes including 2-nitrotoluene and 2-nitro ethylbenzene. For alkyl nitrobenzenes, ease of VNS increased para ortho meta and methyl ethyl iso-propyl. Formation of chlorine-free products upon VNS by methyl dichloro- acetate suggests the involvement of radical anions.

SYNTHESES D'ESTERS OU D'ACIDES α-HALOGENES A PARTIR DES GEM DICYANO EPOXIDES.

α-halogeno esters or α-halogenoacids were easily prepared by selective one pot reaction of gem-dicyano epoxides with halohydric acids in an alcoholic or aqueous media.