4743-55-9

Usage

Molecular structure

A complex structure with a hexahydro-2-benzofuran core.

Physical state

Colorless liquid.

Odor

Distinctive.

Uses

a. Production of fragrances and flavorings.
b. Solvent in various industrial processes.

Natural occurrence

Commonly found in essential oils.

Therapeutic properties

a. Potential anti-inflammatory effects.
b. Potential antimicrobial effects.

Safety concerns

a. Potential health hazards.
b. Toxic effects if ingested or inhaled.

Handling precautions

Should be handled with caution.

Upstream product

• 1708-29-8 2,5-dihydrofuran 
• 106-99-0 buta-1,3-diene 
• 4841-85-4 cis-4-cyclohexene-1,2-dicarboxylic acid diethyl diester 
• 4841-85-4 trans-1,2-bis(ethoxycarbonyl)-4-cyclohexene 
• 10479-72-8 trans-2-Chlormethyl-1-hydroxymethyl-cyclohexen-4 
• 13149-04-7 (rac)-trans-4,5-bis(hydroxymethyl)cyclohex-1-ene 
• 935-79-5 cis-1,2,3,6-tetrahydrophthalic anhydride 
• 10479-72-8 ((1S,6R)-6-Chloromethyl-cyclohex-3-enyl)-methanol 
• 439919-46-7 cis-1,6-dihydroxymethyl-3-cyclohexene 

Downstream Products

• 100697-53-8 4-(Diethyl-methyl-silanyloxymethyl)-5-[(Z)-2-(diethyl-methyl-silanyloxy)-vinyl]-cyclohexene 
• 100697-53-8 4-(Diethyl-methyl-silanyloxymethyl)-5-[(E)-2-(diethyl-methyl-silanyloxy)-vinyl]-cyclohexene 
• 118793-13-8 Trimethyl-(6-phenylselanylmethyl-cyclohex-3-enylmethoxy)-silane 
• 1354698-49-9 (1R,2S,3R,4S,5S,6R)-5,6-bis(acetoxymethyl)cyclohexane-1,2,3,4-tetrayl tetraacetate 
• 1354698-52-4 (1R,2S,3R,4S,5R,6S)-5,6-bis(acetoxymethyl)cyclohexane-1,2,3,4-tetrayl tetraacetate 
• 259670-50-3 meso-3,4-di-t-butyldiphenylsiloxy-8-oxabicyclo[4.3.0]nonane 
• 259670-55-8 C₂₂H₂₂O₆ 
• 259670-59-2 C₂₂H₂₀O₆ 
• 259670-51-4 meso-3,4-dibenzoyloxy-8-oxabicyclo[4.3.0]nonane 

Relevant academic research and scientific papers

Stereoselective synthesis of new rac-quercitols containing hydroxymethyl groups as glucosidase inhibitors

Stereoselective and efficient synthesis of hydroxymethyl-substituted rac-quercitols (13–15) was achieved, starting from cis-furan (Kobayashi, 2008) with photooxygenation reaction, which is readily available by the reduction of cis-phtalic anhydride. α- and β-Glucosidase enzyme activity of the target molecules was evaluated and good inhibitor activity was seen. One- and two-dimensional NMR spectroscopy, IR spectroscopy and X-ray crystallography were utilized in the structure characterization of products.

Synthesis of bishomoinositols and an entry for construction of a substituted 3-oxabicyclo[3.3.1]nonane skeleton

1,3,3a,7a-Tetrahydro-2-benzofuran was used as key compound for the synthesis of various bishomoinositol derivatives. The diene was subjected to an epoxidation reaction for further functionalization of the diene unit. The bisepoxide obtained was submitted

Stereoselective synthesis of bishomo-inositols as glycosidase inhibitors

(Chemical Equation Presented) For the synthesis of various bishomo-inositol derivatives, 1,3,3a,7a-tetrahydro-2-benzofuran was used as the key compound. For further functionalization of the diene unit, the diene was subjected to photooxygenation, epoxidat

Application of oxidative desymmetrization of meso-tetrahydrofurans: Syntheses of functionalized chiral building blocks and of (-)-alloyohimbane

Oxidative desymmetrization of oxygen functionalized mesotetrahydrofurans was successfully achieved (up to 87% ee) through (salen)manganese(III) catalyzed enantiotopic selective C-H oxidation. The enantioselective synthesis of (-)-alloyohimbane (12) has also been achieved in a short step by using oxidative desymmetrization of meso-tetrahydrofuran as the key step.

Cyclisation concertee d'homologues cyclohexaniques et cyclohexeniques du chloro-4 butanol: enthalpies et entropies d'activation; modelisation du chemin reactionel; evolutions d'etats de transition

The relative stabilities of cis and trans stereoisomers of 1-chloromethyl-2-hydroxymethyl cyclohexane and of 4-chloromethyl-5-hydroxymethyl cyclohexene, and of their related bicyclic ethers, have been calculated using the MM2 molecular mechanics program.T