474925-63-8

Basic information

• Product Name: methyl (R)-(+)-4-nitro-3-phenylbutanoate
• Synonyms: methyl (R)-(+)-4-nitro-3-phenylbutanoate
• CAS NO: 474925-63-8
• Molecular Weight: 223.229
• Mol File: 474925-63-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl (R)-(+)-4-nitro-3-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (R)-(+)-4-nitro-3-phenylbutanoate(474925-63-8)
• EPA Substance Registry System: methyl (R)-(+)-4-nitro-3-phenylbutanoate(474925-63-8)

Safety Data

• Hazardous Substances Data: 474925-63-8(Hazardous Substances Data)

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 67-56-1 methanol 
• 563-70-2 bromonitromethane 
• 860772-43-6 (E)-1-(1-methyl-1H-imidazole-2-yl)-3-phenylprop-2-en-1-one 
• 75-52-5 nitromethane 
• 100-52-7 benzaldehyde 
• 5153-67-3 nitrostyrene 
• 34687-03-1 4-nitro-3-phenylbutanoic acid methyl ester 

Downstream Products

• 1078-21-3 (R)-Phenibut 
• 71657-88-0 (4R)-4-phenyl-2-pyrrolidone 
• 852051-17-3 (R)-(+)-4-nitro-3-phenylbutanoic acid 

Relevant articles and documents

Enantioselective Conjugate Addition of 2-Acylimidazoles with Nitroalkenes Promoted by Chiral-at-Metal Rhodium(III) Complexes

An enantioselective conjugate addition of 2-acylimidazoles with nitroalkenes catalyzed by chiral-at-metal rhodium(III) complex under mild reaction conditions was developed, affording versatile γ-nitro ketone skeletons in good yields with excellent enantioselectivities (up to >99% ee). (Figure presented.).

DNA-based catalytic enantioselective Michael reactions in water

High, but not dry: A highly enantioselective Michael reaction in water has been developed by using a simple DNA-based catalyst. Enantioselectivities of up to 99% ee could be obtained by using nitromethane and dimethyl malonate as the nucleophiles and αf,β-unsaturated 2-acylimidazoles as the Michael acceptors. The reactions can be performed on a preparative scale and the catalyst can be recycled. (Chemical Equation Presented).