476471-06-4

Upstream product

• 67-56-1 methanol 
• 821-11-4 1,4-butenediol 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 72900-28-8 2-((Z)-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enyloxy)-tetrahydro-2H-pyran 

Downstream Products

• 1431299-28-3 (R)-3-(4-chlorophenyl)-1-(4-methoxyphenethyl)pyrrolidine 
• 89359-16-0 (S)-β-(4-chlorophenyl)-γ-butyrolactone 
• 147224-51-9 β-(R)-(p-chlorophenyl)-γ-butyrolactone 
• 185342-39-6 5-Bromo-4-(4-chloro-phenyl)-5H-furan-2-one 
• 26717-53-3 4-(4-chlorophenyl)furan-2(5H)-one 
• 26717-54-4 β-(4-chlorophenyl)-γ-butyrolactone 

Relevant academic research and scientific papers

The promoting effect of pyridine ligands in the Pd-catalysed Heck-Matsuda reaction

An efficient Pd-catalyzed arylation reaction of challenging acyclic olefins, in the presence of an organic ligand, has been disclosed. Commercially available cheap pyridine-based ligands are able to promote good to excellent yields for poorly efficient Heck-Matsuda arylation reactions of several allylic alcohols. A wide range of electronically different arenediazonium salts bearing either electron-releasing or withdrawing groups have been used allowing the synthesis of a range of β-aryl-methoxy-lactols. The catalytic system has been optimised, along with the reaction conditions, in order to achieve remarkable yields in less than 1 h.

Palladium-catalyzed arylation of the THP derivative of (Z)-2-butene-1,4- diol with arenediazonium salts and the synthesis of β-aryl-γ- butyrolactones

The reaction of arenediazonium tetrafluoroborates with the THP derivative of (Z)-2-butene-l,4-diol in the presence of Pd(OAc)2 in MeOH at 35 °C gives 4-aryl-2-mefhoxytetrahydrofurans in good to high yields. The reaction tolerates a variety of u