89359-16-0

Basic information

• Product Name: 2(3H)-Furanone, 4-(4-chlorophenyl)dihydro-, (4S)-
• CAS NO: 89359-16-0
• Molecular Formula: C10H9ClO2
• Molecular Weight: 196.633
• Mol File: 89359-16-0.mol
• Article Data: 37

Chemical Properties

• CAS DataBase Reference: 2(3H)-Furanone, 4-(4-chlorophenyl)dihydro-, (4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone, 4-(4-chlorophenyl)dihydro-, (4S)-(89359-16-0)
• EPA Substance Registry System: 2(3H)-Furanone, 4-(4-chlorophenyl)dihydro-, (4S)-(89359-16-0)

Safety Data

• Hazardous Substances Data: 89359-16-0(Hazardous Substances Data)

Upstream product

• 204581-98-6 (R)-4-(4-Chloro-phenyl)-[1,3,2]dioxathiolane 2-oxide 
• 108-59-8 malonic acid dimethyl ester 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 50415-59-3 methyl 2-(4-chlorophenyl)acrylate 
• 51747-43-4 2-(4-chlorophenyl)-acrylic acid 
• 89359-15-9 dimethyl (+)-(S)-2-(4-chlorophenyl)butane-1,4-dioate 
• 45941-96-6 2-(4-chlorophenyl)-3-hydroxypropene 
• 26717-54-4 β-(4-chlorophenyl)-γ-butyrolactone 
• 1679-18-1 4-Chlorophenylboronic acid 
• 52977-95-4 3-(p-chlorophenyl)-4-hydroxybutyric acid 
• 497-23-4 2-buten-4-olide 
• 98272-71-0 γ-acetoxycrotonic acid methyl ester 
• 152714-07-3 3-(4-chlorophenyl)cyclobutanone 
• 476471-06-4 4-(4-chlorophenyl)-2-methoxytetrahydrofuran 

Downstream Products

• 26717-53-3 4-(4-chlorophenyl)furan-2(5H)-one 
• 147224-51-9 β-(R)-(p-chlorophenyl)-γ-butyrolactone 
• 185342-39-6 5-Bromo-4-(4-chloro-phenyl)-5H-furan-2-one 
• 188635-61-2 (R)-3-(4-Chloro-phenyl)-4-iodo-butyric acid ethyl ester 
• 147224-53-1 (R)-ethyl 4-azido-3-(4-chlorophenyl)-1-butanoate 
• 188635-62-3 (R)-4-Azido-3-(4-chloro-phenyl)-butyric acid 
• 63701-55-3 (R)-(-)-baclofen hydrochloride 

Relevant articles and documents

Palladium-Catalyzed Asymmetric Hydroesterification of α-Aryl Acrylic Acids to Chiral Substituted Succinates

A palladium-catalyzed asymmetric hydroesterification of α-aryl acrylic acids with CO and alcohol was developed, preparing a variety of chiral α-substituted succinates in moderate yields with high ee values. The kinetic profile of the reaction progress revealed that the alkene substrate first underwent the hydroesterification followed by esterification with alcohol. The origin of the enantioselectivity was elucidated by density functional theory computation.

Synthesis method of butyrolactone compound

The invention relates to a synthesis method of a butyrolactone compound. The synthesis method comprises the following step: in the presence of a solvent and a cobalt catalyst, converting an oxetane compound shown as general formula I into a butyrolactone compound shown as general formula II through carbonyl insertion ring expansion reaction in an atmosphere of CO and H2. Compared with an existingmethod for synthesizing butyrolactone through oxetane carbonylation ring expansion reaction in a carbon monoxide atmosphere, the synthesis method of a butyrolactone compound provided by the inventionhas the advantages of excellent catalytic activity, excellent chemical selection, wide substrate applicability, mild reaction conditions and the like; compared with other methods for synthesizing butyrolactone compounds, the method provided by the invention has the advantages of wide substrate range, high atom economy, no need of noble metal catalysis and the like, therefore the method has a wideapplication prospect.

Visible-Light Photoredox-Catalyzed Hydroalkoxymethylation of Activated Alkenes Using α-Silyl Ethers as Alkoxymethyl Radical Equivalents

A new neutral silicon-based traceless activation group (TAG) for visible-light photoredox-catalyzed hydroalkoxymethylation of alkenes is presented. This reaction involves in-situ-generated alkoxymethyl radical via single electron oxidation (SET) of α-TMS-substituted ethers, followed by subsequent conjugate addition to activated alkenes. Various functional groups were tolerated both under mild metal and metal-free conditions to provide good to excellent yields. Furthermore, the addition products were transformed to valuable synthetic building blocks, such as carboxylic acids,-butyrolactones, and complex aryl alkyl ethers.