480453-80-3

Upstream product

• 480457-97-4 [2-(4-fluorophenyl)-3-(2-methanesulfonylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]methanol 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 266358-16-1 2-bromo-1-(4-fluorophenyl)-2-(2-methylsulfanylpyrimidin-4-yl)ethanone 
• 695-34-1 2-Amino-4-methylpyridine 
• 217661-99-9 1-(4-fluorophenyl)-2-(2-methylsulphanylpyrimidin-4-yl)-1-ethanone 
• 105250-17-7 2-amino-4-hydroxymethylpyridine 
• 54221-95-3 2-(acetylamino)isonicotinic acid 
• 403-33-8 methyl 4-flurobenzoate 
• 13362-30-6 2-amino-4-ethoxycarbonyl-pyridine 
• 5327-32-2 2-acetylamino-4-methylpyridine 
• 14001-63-9 2-methylthio-4-methylpyrimidine 

Downstream Products

• 480453-86-9 C₂₆H₂₀FN₅O 

Relevant academic research and scientific papers

Synthesis and SAR studies of potent imidazopyridine anticoccidial agents

Diaryl imidazo[1,2-a]pyridine derivatives, such as 6a and 7i, have been synthesized and found to be potent inhibitors of parasite PKG activity. The most potent compounds are the 7-isopropylaminomethyl analog 6a and 2-isopropylamino analog 7i. These compounds are also fully active in in vivo assay as anticoccidial agents at 25 ppm in feed.

Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents

Compounds 10a-10d and 10i are very potent inhibitors of Eimeria tenella cGMP-dependent protein kinase (0.081-0.32 nM) and are very efficacious antiparasitic agents in vivo when administered to chickens at 12.5-25 ppm levels in the feed.