4856-94-4Relevant articles and documents
Multinuclear NMR spectra, 1H-T1 relaxation, conformational behavior, and intramolecular Hδ-····δ+H contacts of N-borane cyclic adducts in solution
Gueizado-Rodriguez,Flores-Parra,Sanchez-Ruiz,Tapia-Benavides,Contreras,Bakhmutov
, p. 3243 - 3246 (2001)
The VT 1H NMR and 1H-NOESY spectra revealed "frozen" envelope conformations in solutions of 1 and 2 with the BR3 groups in equatorial positions. The 1H-T1 relaxation measurements provided determinatio
Visible light-mediated synthesis of amides from carboxylic acids and amine-boranes
Chen, Xuenian,Kang, Jia-Xin,Ma, Yan-Na,Miao, Yu-Qi
supporting information, p. 3595 - 3599 (2021/06/06)
Here, a photocatalytic deoxygenative amidation protocol using readily available amine-boranes and carboxylic acids is described. This approach features mild conditions, moderate-to-good yields, easy scale-up, and up to 62 examples of functionalized amides with diverse substituents. The synthetic robustness of this method was also demonstrated by its application in the late-stage functionalization of several pharmaceutical molecules.
Amine-boranes as Dual-Purpose Reagents for Direct Amidation of Carboxylic Acids
Choudhary, Shivani,Hamann, Henry J.,Ramachandran, P. Veeraraghavan
supporting information, (2020/11/13)
Amine-boranes serve as dual-purpose reagents for direct amidation, activating aliphatic and aromatic carboxylic acids and, subsequently, delivering amines to provide the corresponding amides in up to 99% yields. Delivery of gaseous or low-boiling amines as their borane complexes provides a major advantage over existing methodologies. Utilizing amine-boranes containing borane incompatible functionalities allows for the preparation of functionalized amides. An intermolecular mechanism proceeding through a triacyloxyborane-amine complex is proposed.
