4894-60-4

Upstream product

• 60-29-7 diethyl ether 
• 108-95-2 phenol 
• 2632-88-4 ethyl N,N'-tetraethyldiamidophosphite 
• 22752-34-7 diethyl 1-methyl-3-oxo-1-butenylphosphonate 
• 79948-06-4 O,O-diethyl-N-butyl-N-isobutenyl aminophosphite 
• 86762-96-1 1-diethoxyphosphino-2-ethoxy-2-oxo-1,2-azaphosphetidine 
• 762-04-9 phosphonic acid diethyl ester 
• 64-17-5 ethanol 
• 180906-74-5 C₁₆H₂₃O₅P 
• 4712-55-4 diphenyl hydrogen phosphite 

Downstream Products

• 66567-80-4 trichloromethyl-phosphonic acid ethyl ester-phenyl ester 
• 7526-28-5 ethyl phenyl ethylphosphonate 
• 5301-46-2 phosphoric acid ethyl ester-(2,2-dichloro-vinyl ester)-phenyl ester 
• 36219-53-1 phosphoric acid ethyl ester-isopropenyl ester-phenyl ester 
• 110553-37-2 acetonyl-phosphonic acid ethyl ester-phenyl ester 
• 55549-60-5 2-phenoxy-[1,2]oxaphosphinane 2-oxide 
• 589-57-1 diethyl phosphorylchloridite 
• 54377-92-3 ethyl phenyl chlorophosphite 
• 93-99-2 benzoic acid phenyl ester 
• 371-22-2 fluorophosphoric acid diethyl ester 
• 3426-89-9 phenyl phosphorodichloridite 
• 106870-47-7 Ethyl-phosphoramidic acid ethyl ester phenyl ester 
• 31460-05-6 methyl ethylphenylphosphonoacetate 
• 118433-67-3 ethyl phenyl benzoylphosphonate 

Relevant academic research and scientific papers

Selective synthesis of organophosphites

Disclosed herein is a process for the selective synthesis of triorganophosphites intermediates, including chloridites and dichloridites, from PX3 (X=Cl, Br or I), alcoholos and triorganoamines where alcohol and triorganoamine are added either (a) separately and concurrently, or (b) alternating equimolar portions of amine and alcohol.

Phosphitylation via the Mitsunobu reaction

Treatment of a dialkyl phosphite with triphenylphosphine and diisopropyl azodicarboxylate in toluene, followed by addition of an alcohol, results in the formation of the corresponding trialkyl phosphite. Similarly, dialkyl phosphonites can be synthesised from monoalkyl phosphites (alkyl phosphinates).

Studies on aryl H-phosphonates. 3. Mechanistic investigations related to the disproportionation of diphenyl H-phosphonate under anhydrous basic conditions

Diphenyl H-phosphonate undergoes under anhydrous reaction conditions a base-promoted disproportionation to triphenyl phosphite and phenyl H- phosphonate. On the basis of 31P NMR data the most likely mechanism for this transformation was proposed. In order to substantiate these findings and to get a deeper insight into the chemistry of aryl H-phosphonate esters, we carried out also some studies on activation of phenyl and diphenyl H- phosphonates with various condensing agents. We found that aryl vs alkyl esters of phosphonic acid often follow different reaction pathways during the activation, and this can most likely be traced back to higher electrophilicity of the phosphorus centre and to higher reactivity of the P- H bonds in aryl H-phosphonate derivatives.