4946-22-9Relevant academic research and scientific papers
Imposing Latency in Ruthenium Sulfoxide-Chelated Benzylidenes: Expanding Opportunities for Thermal and Photoactivation in Olefin Metathesis
Alassad, Nebal,Goldberg, Israel,Kozuch, Sebastian,Lemcoff, N. Gabriel,Nechmad, Noy B.,Rozenberg, Illya,Segalovich-Gerendash, Gal
, p. 4827 - 4834 (2020/06/01)
Herein we show the design and synthesis of an electron-rich, sulfoxide-chelated, ruthenium benzylidene. In contrast to previously reported sulfoxide-chelated ruthenium benzylidenes, this complex is more stable in a cis-dichloro conformation and is thus latent in typical olefin metathesis reactions. The complex was characterized by NMR, UV-vis, and X-ray spectroscopy, alongside density functional theory computations. The latent precatalyst could be activated thermally and, depending on the solvent, by UV-C or visible light. In addition, an original "thermo-chromatic" orthogonal sequence was developed, further improved by the use of a thioether chelated complex, where a divergent two-step synthesis can lead to a dihydrofuran or a dihydropyran depending only on the order by which the different stimuli, heat or light, are applied.
The unexpected desulfurization of 4-aminothiophenols
Mulder, Peter,Mozenson, Olga,Lin, Shuqiong,Ingold
, p. 2379 - 2386 (2007/10/03)
Thermolysis of 4-aminophenyl benzyl sulfide at 523 K in the hydrogen donor solvent (HDS), 9,10-dihydroanthracene (AnH2), gave 4-aminothiophenol and toluene as the predominant products of the homolytic S-C bond cleavage. Under these conditions, a portion of the 4-aminothiophenol was desulfurized to aniline with first-order kinetics and with a rate constant estimated by kinetic modeling to be 7.0 × 10-6 s-1. Starting with 4-NH2C6H4SH at 523 K, it was found that sulfur loss was more efficient in the non-HDSs, anthracene and hexadecane, than in AnH2. Under similar (competitive) reaction conditions, YC 6H4SHs with Y = H, 4-CN, and 3-CF3 were completely inert; with Y = 4-CH3O, there was some very minor desulfurization, whereas with Y = 4-N(CH3)2 and 4-N(CH3)(H), the sulfur extrusions were as fast as that for Y = 4-NH2. We tentatively suggest that this apparently novel reaction is a chain process initiated by the bimolecular formation of diatomic sulfur, S2, followed by a reversible addition of ground state, triplet 3S2 to the thiol sulfur atom, 4-NH2C 6H4S↑(SS↑)H, and insertion into the S-H bond, 4-NH2C6H4SSSH. In a cascade of reactions, aniline and S8 are formed with the chains being terminated by reaction of 4-NH2C6H4S↑(SS↑)H with 4-NH2C6H4SH. Such a reaction mechanism is consistent with the first-order kinetics. That this reaction is primarily observed with 4-YC6H4SH having Y = N(CH3) 2, N(CH3)(H), and NH2 is attributed to the fact that these compounds can exist as zwitterions.
HISTONE DEACETYLASE INHIBITORS
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Page 49, (2008/06/13)
The present invention provides histone deacetylase inhibitors of general formula (I), process for the preparation of such compounds and uses of the compounds in medicine.
Facile introduction of SH group on aromatic substrates via electrophilic substitution reactions
Becht, Jean-Michel,Wagner, Alain,Mioskowski, Charles
, p. 5758 - 5761 (2007/10/03)
Herein, we describe a mild and efficient two-step procedure to introduce a thiol group on aromatic substrates. First, reaction with an activated sulfoxide leads to an arylsulfonium salt intermediate. Then, two successive β-elimination-based dealkylation reactions afford the desired arylthiols in good to excellent yields.
Polymerisation inhibitor
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, (2008/06/13)
A monomer composition, stabilized against premature polymerization, comprising: a) an ethylenically unsaturated monomer or mixture of monomers polymerizable by free radical initiation, and b) an effective amount, sufficient to inhibit premature polymerization of component (a) of a mixture of: i) 1 to 99% by weight, based on the total weight of components (i) and (ii), of a mixture of at least one aromatic amine and at least one organic acid in a molar ratio of 10:1 to 1:10, and ii) 99 to 1% by weight, based on the total weight of components (i) and (ii), of at least one stable radical compound.
Phthalimidesulfenyl chloride. x1. a synthetic equivalent of hs+ and+s-s+ species in electrophilic aromatic substitutions
Capozzi, Giuseppe,Falciani, Chiara,Menichetti, Stefano,Nativi, Cristina
, p. 227 - 232 (2007/10/03)
The reaction of phthalimidesulfenyl chloride, 1, with activated arenes provides monosubstituted phthalimidesulfenyl derivatives 3 which can be easily transformed into the corresponding disulfides 7, thiols 8 and masked thiols 9.
Preparation of t-butyl sulfides by a novel ligand-transfer reaction of aryl thiocyanates
Toste, F. Dean,Still, Ian W. J.
, p. 4361 - 4364 (2007/10/02)
Aryl t-butyl sulfides are prepared in good to excellent yields by the reaction of aryl thiocyanates with (t-Bu)2Cu(CN)Li2.
