4969-62-4

Basic information

• Product Name: Pyridine, 4-(3-phenyl-1,2,4-oxadiazol-5-yl)-
• CAS NO: 4969-62-4
• Molecular Formula: C13H9N3O
• Molecular Weight: 223.234
• Mol File: 4969-62-4.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Pyridine, 4-(3-phenyl-1,2,4-oxadiazol-5-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-(3-phenyl-1,2,4-oxadiazol-5-yl)-(4969-62-4)
• EPA Substance Registry System: Pyridine, 4-(3-phenyl-1,2,4-oxadiazol-5-yl)-(4969-62-4)

Safety Data

• Hazardous Substances Data: 4969-62-4(Hazardous Substances Data)

Upstream product

• 3731-53-1 4-(aminomethyl)pyridine 
• 100-52-7 benzaldehyde 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 1570-45-2 isonicotinic acid ethylester 
• 100-47-0 benzonitrile 
• 613-92-3 N-hydroxyl-benzamidine 
• 14254-57-0 4-(chlorocarbonyl)pyridine 
• 108-89-4 picoline 
• 1670-14-0 benzamidine monohydrochloride 
• 891992-11-3 N'-(isonicotinoyloxy)benzimidamide 
• 1594-57-6 pyridine-4-carboxamidoxime 
• 698-16-8 benzohydroximoyl chloride 
• 1448510-49-3 3-phenyl-5-(4-pyridyl)-1,2,4-oxadiazole-4-oxide 
• 55-22-1 pyridine-4-carboxylic acid 

Relevant articles and documents

Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines

The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazole and quinazoline derivatives from readily available benzaldehyde, benzylamine and hydroxylamine or aniline has been developed. Both the cascade reaction sequences involves nucleophilic addition of C?N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation. This synthesis methodology demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provides strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials. (Figure presented.).

Convenient entry to N-pyridinylureas with pharmaceutically privileged oxadiazole substituents via the acid-catalyzed C[sbnd]H activation of N-oxides

Pyridine-N-oxides bearing a pharmacophoric oxadiazole moiety could be C[sbnd]H functionalized via the acid-catalyzed reaction with dialkylcyanamides, providing access to hitherto undescribed pyridine-2-yl substituted ureas, which have potential as “lead-l

A convenient and mild method for 1,2,4-oxadiazole preparation: Cyclodehydration of O-acylamidoximes in the superbase system MOH/DMSO

Herein, we reported a general, convenient, and efficient synthesis of 3,5-disubstituted-1,2,4-oxadiazoles via cyclodehydration of O-acylamidoximes in the superbase system MOH/DMSO (M = Li, Na, K). Excellent isolated yields (up to 98%) were attained within