500992-13-2

Usage

Uses

Used in Organic Synthesis:
2-PHENYL-1H-INDOL-6-AMINE is used as a building block in organic synthesis for the creation of various chemical compounds due to its reactive amine group and aromatic structure.
Used in Pharmaceutical Research:
In pharmaceutical research, 2-PHENYL-1H-INDOL-6-AMINE is used as a key intermediate for the development of new drugs, leveraging its potential pharmacological properties.
Used in Dye and Pigment Production:
2-PHENYL-1H-INDOL-6-AMINE is utilized as a precursor in the production of dyes and pigments, capitalizing on its aromatic system to impart color.
Used in Cancer Treatment Research:
2-PHENYL-1H-INDOL-6-AMINE is explored as a potential agent in cancer treatment, with ongoing research into its effects on tumor growth and progression.
Used in Chemical Reactions as a Precursor:
As a precursor in various chemical reactions, 2-PHENYL-1H-INDOL-6-AMINE is instrumental in the synthesis of a range of compounds across different industries.

Upstream product

• 7647-01-0 hydrogenchloride 
• 58665-14-8 p-[1-benzoyl-1'-(2,4-dinitrophenyl)methane] 
• 64-19-7 acetic acid 
• 38351-32-5 <2,4-Dinitro-phenyl>-benzoyl-essigsaeure-ethylester 
• 584-48-5 2,4-dinitrobromobenzene 
• 10403-47-1 2-bromo 5-nitroaniline 
• 536-74-3 phenylacetylene 
• 532-27-4 1-chloroacetophenone 
• 99-65-0 meta-dinitrobenzene 
• 500992-05-2 N-[(5'-nitro-2'-phenylethynyl)phenyl]butyramide 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 945655-38-9 6-amino-2-phenyl-1H-indole-3-carboxylic acid ethyl ester 
• 500992-30-3 6-nitro-2-phenyl-1H-indole 

Relevant academic research and scientific papers

5-SULFAMOYL-2-HYDROXYBENZAMIDE DERIVATIVES

The invention is directed to substituted salicylamide derivatives. Specifically, the invention is directed to compounds according to Formula (I): wherein R, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof. The compounds of the invention are inhibitors of CD73 and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, the treatment of HIV, autoimmune diseases, infections, atherosclerosis, and ischemia–reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Straightforward selective preparation of nitro- or amino-indoles from 2-halonitroanilines and alkynes. First synthesis of 7-amino-5-nitroindoles

A one-pot selective synthesis of 2-substituted C5-, C6-, and C7-nitro- or amino-indoles has been developed from 2-halonitroanilines. These two types of nitrogen-substituted indoles have been selectively obtained by only varying the solvent used in the tandem Sonogashira coupling/heteroannulation reaction. Moreover, from commercially available 2-bromo-4,6-dinitroaniline an unprecedented in situ selective reduction of one of the nitro groups has allowed the synthesis of new 7-amino-5-nitro-2-substituted indoles.

A practical synthesis of 2-aryl-indole-6-carboxylic acids

A practical synthesis of 2-aryl-indole-6-carboxylic acids was developed via a sequence consisting of SNAr reaction, reductive cyclization, hydrolysis and decarboxylation. This process is efficient in terms of operational simplicity, cost effectiveness and is amenable to large scale production.

Chemistry of aminophenols. Part 2: A general and efficient synthesis of indoles possessing a nitrogen substituent at the C4, C5, C6, and C7 positions

A general and efficient synthesis of indoles possessing a nitrogen substituent at the C4, C5, C6, and C7 positions has been developed. Starting from commercially available nitro 2-aminophenols, 5-, 6-, and 7-arenesulfamoylindoles were synthesized via a ba