5014-22-2

Usage

Chemical Type

Methyl ester derivative of a benzoic acid compound

Application

Used in medicinal chemistry and pharmaceuticals

Biological Activities

Being studied for potential therapeutic applications

Structural Features

Consists of benzene rings and hydroxyl groups

Handling

Requires careful handling due to potential reactivity and toxicity

Upstream product

• 125304-80-5 methyl baeomycesate 
• 64-19-7 acetic acid 
• 856076-92-1 2-acetoxy-4-methoxy-3,6-dimethyl-benzoic acid 
• 644-66-6 4-(3-formyl-2-hydroxy-4-methoxy-6-methylbenzoyloxy)-2-hydroxy-3,6-dimethylbenzoic acid 
• 31581-32-5 ethyl 2,4-dihydroxy-3,6-dimethylbenzoate 
• 4707-47-5 2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester 
• 479-26-5 2-hydroxy-4-methoxy-3,6-dimethylbenzoic acid 
• 186581-53-3 diazomethane 
• 17636-16-7 barbatic acid 
• 479-20-9 atranorin 

Relevant academic research and scientific papers

Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth. 1. Novel analogues of barbatic and diffractaic acid

A series of barbatic and diffractaic acid analogues has been synthesized and evaluated as inhibitors of leukotriene B4 (LTB4) biosynthesis and as antiproliferative agents. The 4-O-demethyl barbatic and diffractaic acid derivatives were among the most active compounds in both assays. In particular, ethyl 4-O-demethylbarbatate was the most potent LTB4 biosynthesis inhibitor of this series, with an IC50 value in the submicromolar range. Because the compounds did not show appreciable reactivity against a stable free radical, 2,2-diphenyl-1-picrylhydrazyl, and did not produce appreciable amounts of deoxyribose degradation as a measure of their potency to generate hydroxyl radicals, a simple redox effect could not explain their biological activity. Also, there was no nonspecific cytotoxicity as documented by the activity of lactate dehydrogenase released from the cytoplasm of keratinocytes, which was in the control range.