50397-69-8

Upstream product

• 67-56-1 methanol 
• 3406-76-6 (4-bromophenylthio)acetic acid 
• 104-95-0 (4-bromophenyl)thioanisole 
• 96-32-2 bromoacetic acid methyl ester 
• 934-71-4 1-bromo-4-(methylsulfinyl)benzene 
• 106-53-6 para-bromobenzenethiol 
• 96-34-4 methyl chloroacetate 
• 186581-53-3 diazomethane 

Downstream Products

• 63216-00-2 p-bromophenylsulfinylacetic acid methyl ester 
• 50397-65-4 methyl 2-((4-bromophenyl)sulfonyl)acetate 
• 3406-76-6 (4-bromophenylthio)acetic acid 
• 250736-42-6 5-bromobenzo[b]thiophen-3(2H)-one 1,1-dioxide 
• 53920-28-8 2-((4-bromophenyl)thio)acetyl chloride 
• 63216-02-4 methyl 2-((4-bromophenyl)thio)-2-(4-methoxyphenyl)acetate 

Relevant academic research and scientific papers

Sulfoxide Reduction/C(sp3)-S Metathesis Cascade in Ionic Liquid

A sulfoxide reduction/C-S bond metathesis cascade between sulfoxides and alkyl bromides has been developed to access high-value sulfides without the use of any catalysts or bases. In this cascade, classical Kornblum oxidation is employed to reduce sulfoxides with alkyl bromides in ionic liquid. This protocol features high functional tolerance, mild conditions, promising scalability, and sustainable solvents.

CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

ACYCLIC CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

N-Acylhydrazones as inhibitors of PDE10A

Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease.

Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs)

Several classes of arylsulfone-based MMP-2/-9 inhibitors utilizing 6- to 8-membered heterocyclic rings as zinc-binding groups (ZBGs) have been synthesized and their enzyme inhibitory activities were evaluated. Although a number of 6- and 7-membered hetero

Applicability of Hammett Equation to Kinetics of Acid-catalysed Esterification of meta- and para-Substituted Phenylmercaptoacetic and Phenylsulphonylacetic Acids with Methanol

Rate constants have been determined for the acid-catalysed esterification of meta- and para-substituted phenylmercaptoacetic and phenylsulphonylacetic acids with methanol using hydrogen chloride as catalyst.The lower reactivities of phenylmercaptoacetic acids compared to those of the corresponding phenoxyacetic acids are discussed.

EFFECT OF MOLECULAR STRUCTURE ON OPTICAL PROPERTIES OF SULFOXIDE SYSTEMS. p-BROMOPHENYLSULFINYLACETIC ACIDS AND SOME OF THEIR DERIVATIVES. PART II

The synthesis and principal properties of p-bromophenylsulfinylacetic and p-bromophenylsulfonylacetic acids are described.The racemic sulfoxide was resolved by fractional crystallization of its diastereomeric salts with optically active bases.The configur