50733-54-5

Basic information

• Product Name: 9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
• Synonyms: 9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate;9-Bromopregn-4-ene-11,17,21-triol-3,20-dione 21-acetate
• CAS NO: 50733-54-5
• Molecular Formula: C₂₃H₃₁BrO₆
• Molecular Weight: 483.39
• Mol File: 50733-54-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate(50733-54-5)
• EPA Substance Registry System: 9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate(50733-54-5)

Safety Data

• Hazardous Substances Data: 50733-54-5(Hazardous Substances Data)

Upstream product

• 7753-60-8 anecortave 
• 113862-93-4 21-acetoxy-17-hydroxy-11α-methanesulfonyloxy-pregn-4-ene-3,20-dione 
• 79-15-2 N-bromoacetamide 
• 566-35-8 Epicortisol 

Downstream Products

• 127-31-1 Fludrocortisone 
• 514-36-3 fludrocortisone acetate 
• 357-09-5 9α-Fluor-11β-hydroxy-3,17-dioxo-androsten-4 
• 79-60-7 9α-fluorocortisone 
• 29042-01-1 21-acetoxy-9-chloro-11β,17-dihydroxy-pregn-4-ene-3,20-dione 
• 6635-85-4 21-acetoxy-11β,17-dihydroxy-9-methoxy-pregn-4-ene-3,20-dione 
• 50-04-4 Cortisone acetate 
• 4383-30-6 9β,11β-epoxy-17α-hydroxypregna-4‐ene-3,20-dione-21-acetate 
• 50-03-3 hydrocortisone acetate 
• 112571-03-6 21-acetoxy-11β,17-dihydroxy-pregna-4,8-diene-3,20-dione 
• 4383-30-6 21-acetoxy-9,11β-epoxy-17-hydroxy-9β-pregn-4-ene-3,20-dione 
• 10072-97-6 9,11β-epoxy-17,21-dihydroxy-9β-pregn-4-ene-3,20-dione 

Relevant articles and documents

Preparation method of high-purity hydrocortisone

The invention discloses a preparation method of high-purity hydrocortisone, and belongs to the technical field of preparation and processing of medicines. According to the method, 17alpha-hydroxypregna-4, 9 (11)-diene-3, 20-diketone-21-acetate is used as a starting material, and the high-purity hydrocortisone is prepared through three steps of bromo-hydroxyl, debromination and hydrolysis. According to the preparation method of the high-purity hydrocortisone disclosed by the invention, the reaction process can be effectively shortened by improving the defects of a traditional process, the generation of impurities during the reaction process is controlled, the use of iodine with characteristics of high toxicity and environmental unfriendliness is avoided, the environmental pollution is reduced, and the method has characteristics of high overall conversion rate, simple operation and wide market prospect, and is suitable for industrial production.

Preparation method of cortisone acetate

The invention relates to a preparation method of cortisone acetate. Anecortave acetate is used as a raw material and sequentially takes addition, oxidization and reduction reaction to obtain the anecortave acetate. The method comprises the following reaction steps of A, addition reaction: under the nitrogen production, adding the anecortave acetate into an organic solvent; adding a halogenating reagent and an acid catalyst to obtain an intermediate II; B, oxidization reaction: under the nitrogen gas protection, adding the compound II into the organic solvent; adding an oxidizing agent to obtain an intermediate III; C, reduction reaction: under the nitrogen gas production, adding the compound III into the organic solvent; adding an acid catalyst and a reducing agent to obtain a target product of the cortisone acetate IV. The method has the advantages that the raw materials can be easily obtained; the reaction steps are few; the quality and the yield achieve the obvious competitiveness; in addition, the pollution on the environment is reduced.

Preparation method of hydrocortisone acetate

The invention belongs to the field of preparation of steroid drugs and particularly relates to a preparation method of hydrocortisone acetate. The preparation method comprises steps as follows: a bromohydroxy compound is synthesized from a compound C5 as a raw material through a bromohydroxy reaction, a crude hydrocortisone acetate product is produced through a debromination reaction, and finally, a refined hydrocortisone acetate product is obtained through refining, wherein alkali halide is added as a catalyst of the bromohydroxy reaction and a feeding mass ratio of the compound C5 to alkali halide is 1:(0.08-0.1). The preparation method of hydrocortisone acetate has the advantages as follows: alkali halide is adopted as the catalyst of the bromohydroxy reaction, so that the key of the problem that the reaction is incomplete in the bromohydroxy reaction process is solved, and one novel preparation method of hydrocortisone acetate with stable product quality and higher yield is provided.

9α-dehalogenation process

The present invention involves improved processes for the dehalogenation of 9α-halosteroids (I) STR1 to produce the corresponding 11β-hydroxy steroids (II) STR2 which are known to be useful as pharmaceutical, where the improvements comprise (1) adding the 9α-halo steroid (I) to the chromium and (2) using catalytic amounts of chromium in the presence of a means of converting chromium (II) to chromium (III).