50892-62-1

Basic information

• Product Name: 8-Chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one
• Synonyms: 8-CHLORO-11-OXO-10,11-DIHYDRO-5H-DIBENZO-1,4-DIAZEPINE;8-CHLORO-5,10-DIHYDRO-11H-DIBENZO[B,E][1,4]-DIAZEPIN-11-ONE;8-CHLORO-5,10-DIHYDRODEBENZO[B,E][1,4]DIAZEPIN-11-ONE;8-chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one;8-CHLORO-10,11-DIHYDRO-5H-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE;8-Chloro-11-oxo-10,11-dihydro-5h-debenzo-1,4-diazepine;8-Chloro-11-Oxo-10,11-Dihydro-5H-Debenzo-1,4-Diazepine(ForClozapine);8-Chloro-11-oxo-10,11-Dihydro-5 H-Dibenzo-1,4-Diazepine (intermediate of clozapine)
• CAS NO: 50892-62-1
• Molecular Formula: C₁₃H₉ClN₂O
• Molecular Weight: 244.68
• Product Categories: (intermediate of clozapine);Aromatics Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 50892-62-1.mol
• Article Data: 23

Chemical Properties

• Melting Point: 233-236°C
• Boiling Point: 334.4 °C at 760 mmHg
• Flash Point: 156 °C
• Appearance: white solid
• Density: 1.327 g/cm³
• Vapor Pressure: 0.000128mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: -20?C Freezer
• Solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
• PKA: 11.68±0.20(Predicted)
• Stability: Store in Freezer
• CAS DataBase Reference: 8-Chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one(50892-62-1)
• EPA Substance Registry System: 8-Chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one(50892-62-1)

Safety Data

• Hazardous Substances Data: 50892-62-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 50892-62-1 differently. You can refer to the following data:
1. 8-Chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-one can be a useful intermediate for the preparation of pharmaceutical actives and fine chemicals.
2. A useful intermediate for the preparation of pharmaceutical actives and fine chemicals. Antipsychotic drug.

InChI:InChI=1/C13H9ClN2O/c14-8-5-6-11-12(7-8)16-13(17)9-3-1-2-4-10(9)15-11/h1-7,15H,(H,16,17)

Upstream product

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• 88-67-5 2-Iodobenzoic acid 
• 552-16-9 ortho-nitrobenzoic acid 
• 88-72-2 1-methyl-2-nitrobenzene 
• 108-88-3 toluene 
• 89-63-4 4-Chloro-2-nitroaniline 
• 881-51-6 N-(4-chloro-2-nitrophenyl)-acetamide 

Downstream Products

• 98374-72-2 8-Chlor-5,10-dihydro-5-<<4-(3,4,5-trimethoxybenzoy)-1-piperazinyl>acetyl>-11H-dibenzo<1,4>diazepin-11-on-hydrochlorid 
• 98374-54-0 8-Chlor-5,10-dihydro-5--11H-dibenzo<1,4>-diazepin-11-on 
• 98374-71-1 8-Chlor-5,10-dihydro-5-<<4-(3,4,5-trimethoxybenzoy)-1-piperazinyl>acetyl>-11H-dibenzo<1,4>diazepin-11-on 
• 98374-55-1 8-Chlor-5,10-dihydro-5--11H-dibenzo<1,4>-diazepin-11-on-hydrochlorid 
• 1179874-27-1 8-chloro-11-[4-(2-phenoxyethyl)piperazino]5H-dibenzo[b,e][1,4]diazepine 
• 1179874-30-6 8-chloro-11-[4-(3-phenoxypropyl)piperazino]5H-dibenzo[b,e][1,4]diazepine 
• 1024010-08-9 ethyl 4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)benzoate 
• 5786-21-0 clozaril 
• 6104-71-8 N-desmethylclozapine 
• 1008109-24-7 C₂₁H₁₇ClN₂O₂ 
• 1219027-37-8 8-chloro-11-(4-(3-(2-chlorophenoxy)propyl)piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine 

Relevant articles and documents

Hydrazides of clozapine: A new class of D1 dopamine receptor subtype selective antagonists

Acylated and aroylated hydrazinoclozapines are highly potent dopamine D1 antagonists that show remarkable selectivity over other dopamine receptors. The most potent compound in this series is the 2,6-dimethoxybenzhydrazide 33 with a D1 Ki of 1.6 nM and 212-fold selectivity over D2 receptor.

BROAD SPECTRUM GPCR BINDING AGENTS

Provided herein are broad-spectrum G-Protein coupled receptor (GPCR) binding agents, detectable/isolatable compounds comprising such binding agents (e.g., broad-spectrum GPCR binding agents linked to a functional element and/or solid surface), and methods of use thereof for the detection/isolation of GPCRs.

Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D1/D2 receptor

Clozapine-like compound without agranulocytosis risk is need to cure the treatment resistant schizophrenia (TRS). We discovered (S)-3 as Clozapine-like dopamine D2/D1 receptor selectivity and improved reactive metabolites formation profile by the modification of piperazine moiety in Clozapine. The optimization of (S)-3 gave compound 5 to be best compound (approximately 10-fold stronger affinity for D2/D1 receptor and similar D2/D1 selectivity ratio with Clozapine). Clozapine-like D2/D1 receptor occupancy profile was proved by in vivo evaluation. In addition, the reactive metabolites derived agranulocytosis risk of compound 5 was considered to be lower than Clozapine. The pharmacology detail of compound 5 is being investigated to develop it for TRS treatment.