60091-87-4

Basic information

• Product Name: 2-[(4-CHLORO-2-NITROPHENYL)AMINO]-BENZOIC ACID
• Synonyms: 2-[(4-CHLORO-2-NITROPHENYL)AMINO]-BENZOIC ACID;2-(4-CHLORO-2-NITRIPHENYL)AMINOBENZOIC ACID;2-[(4-CHLORO-2-NITROPHENYL)AMINO]-BENZOIC ACID(WXG02137);Clozapine Impurity 7
• CAS NO: 60091-87-4
• Molecular Formula: C₁₃H₉ClN₂O₄
• Molecular Weight: 292.67
• Mol File: 60091-87-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 246-247 °C(Solv: ethanol (64-17-5))
• Boiling Point: 445.9 °C at 760 mmHg
• Flash Point: 223.5 °C
• Appearance: /
• Density: 1.525 g/cm³
• Vapor Pressure: 9.86E-09mmHg at 25°C
• Refractive Index: 1.698
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 3.59±0.36(Predicted)
• CAS DataBase Reference: 2-[(4-CHLORO-2-NITROPHENYL)AMINO]-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-CHLORO-2-NITROPHENYL)AMINO]-BENZOIC ACID(60091-87-4)
• EPA Substance Registry System: 2-[(4-CHLORO-2-NITROPHENYL)AMINO]-BENZOIC ACID(60091-87-4)

Safety Data

• Hazardous Substances Data: 60091-87-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 60091-87-4 differently. You can refer to the following data:
1. 2-[(4-Chloro-2-nitrophenyl)amino]benzoic Acid is an diazepinomicin derivative with potential antcancer activity. 2-[(4-Chloro-2-nitrophenyl)amino]benzoic Acid is also an impurity in the synthesis of Clozepine, an antipsychotic.
2. 2-[(4-Chloro-2-nitrophenyl)amino]benzoic Acid is an diazepinomicin derivative with potential antcancer activity. 2-[(4-Chloro-2-nitrophenyl)amino]benzoic Acid is also an impurity in the synthesis of Clozepine (C587500), an antipsychotic.

InChI:InChI=1/C13H9ClN2O4/c14-8-5-6-11(12(7-8)16(19)20)15-10-4-2-1-3-9(10)13(17)18/h1-7,15H,(H,17,18)

Upstream product

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• 88-72-2 1-methyl-2-nitrobenzene 
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• 41513-04-6 2-chloro-5-bromonitrobenzene 
• 345-18-6 2-fluoro-5-chloronitrobenzene 

Downstream Products

• 50373-22-3 8,11-dichloro-5H-dibenzo[b,e][1,4]-diazepine 
• 62889-51-4 methyl 2-[(4-chloro-2-nitrophenyl)amino]benzoate 
• 69414-55-7 C₁₃H₈Cl₂N₂O₃ 
• 5786-21-0 clozaril 
• 65514-72-9 N-(4-chloro-2-nitrophenyl)-N-{2-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amine 
• 98374-55-1 8-Chlor-5,10-dihydro-5--11H-dibenzo<1,4>-diazepin-11-on-hydrochlorid 
• 98374-71-1 8-Chlor-5,10-dihydro-5-<<4-(3,4,5-trimethoxybenzoy)-1-piperazinyl>acetyl>-11H-dibenzo<1,4>diazepin-11-on 
• 98374-54-0 8-Chlor-5,10-dihydro-5--11H-dibenzo<1,4>-diazepin-11-on 
• 98374-72-2 8-Chlor-5,10-dihydro-5-<<4-(3,4,5-trimethoxybenzoy)-1-piperazinyl>acetyl>-11H-dibenzo<1,4>diazepin-11-on-hydrochlorid 

Relevant articles and documents

Identification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors

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NOVEL and IMPROVED SYNTHESIS OF ANTIPSYCHOTIC DRUG

The present invention relates to novel as well as improved process for the preparation of Clozapine of Formula I which involves anti-narcotic and highly cost effective raw materials.

COMPOUNDS WITH 7-MEMBER CYCLE AND THE PHARMACEUTICAL USE THEREOF FOR PREVENTING AND TREATING DIABETES AND METABOLISM SYNDROME

The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.