67990-66-3

Basic information

• Product Name: N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID
• Synonyms: 2[(2-Amino-4-chlorophenyl)amino]benzoicacid;N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID;TIMTEC-BB SBB001005;LABOTEST-BB LT00012600;D2-((2-AMINO-2-CARBOXY-4-CHLOROPHENYL)AMINO)BENZOIC ACID;D2-((2-AMINO-2-CARBOXY-4-CHLOROPENYL)AMINO)BENZOIC ACID;Benzoicacid, 2-[(2-aMino-4-chlorophenyl)aMino]-;N-(2-Amino-4-chlorophenyl)anthranilic acid 97%
• CAS NO: 67990-66-3
• Molecular Formula: C₁₃H₁₁ClN₂O₂
• Molecular Weight: 262.69
• Product Categories: C13 to C42+;Carbonyl Compounds;Carboxylic Acids
• Mol File: 67990-66-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 191 °C (dec.)(lit.)
• Boiling Point: 442.4 °C at 760 mmHg
• Flash Point: 221.4 °C
• Appearance: /
• Density: 1.441 g/cm³
• Vapor Pressure: 1.32E-08mmHg at 25°C
• Refractive Index: 1.716
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.60±0.36(Predicted)
• CAS DataBase Reference: N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID(67990-66-3)
• EPA Substance Registry System: N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID(67990-66-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 67990-66-3(Hazardous Substances Data)

Usage

Uses

N-(2-Amino-4-chlorophenyl)anthranilic acid may be used in chemical synthesis studies.

InChI:InChI=1/C13H11ClN2O2/c14-8-5-6-12(10(15)7-8)16-11-4-2-1-3-9(11)13(17)18/h1-7,16H,15H2,(H,17,18)

Upstream product

• 60091-87-4 2-(4-Chlor-2-nitrophenyl)aminobenzencarbonsaeure 
• 881-51-6 N-(4-chloro-2-nitrophenyl)-acetamide 
• 89-63-4 4-Chloro-2-nitroaniline 
• 108-88-3 toluene 
• 88-72-2 1-methyl-2-nitrobenzene 
• 552-16-9 ortho-nitrobenzoic acid 
• 88-67-5 2-Iodobenzoic acid 
• 106-47-8 4-chloro-aniline 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 118-91-2 ortho-chlorobenzoic acid 
• 89-61-2 2,5-dichloronitrobenzene 
• 118-92-3 anthranilic acid 
• 41513-04-6 2-chloro-5-bromonitrobenzene 

Downstream Products

• 76443-18-0 2-(2-amino-4-chlorophenylamino)benzamide 
• 182679-34-1 2-[4-chloro-2-(3-phenylpropionylamino)phenylamino]benzamide 
• 182679-33-0 2-[4-chloro-2-(3-phenylureido)phenylamino]benzamide 
• 1024010-08-9 ethyl 4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)benzoate 
• 50373-22-3 8,11-dichloro-5H-dibenzo[b,e][1,4]-diazepine 

Relevant articles and documents

Identification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors

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Clozapine intermediate as well as synthesis method and application thereof (by machine translation)

The invention discloses a clozapine intermediate and a synthesis method and application thereof, and belongs to the technical field of drug synthesis. The synthesis method comprises 1) synthesis of 2 - [(2 - amino -4 - chlorophenyl) amino] benzoic acid, 2) 8 - chlorine -5, 10 - dihydro - 111111H-dibenzo [b, e] [1, 4]-diazepine -11 - ketone. The synthesis method of the clozapine intermediate is simple in preparation process, recyclable in solvent, easy to operate and control, good in color, good in quality, high in purity and high in yield, can be directly used for production and use, and has good practicability. (by machine translation)

Design, synthesis and anticancer activity evaluation of diazepinomicin derivatives

A series of diazepinomicin derivatives were synthesized and evaluated in vitro for their growth inhibitory activity against the human carcinoma cell lines. The results indicated the anticancer selectivity of this kind of compounds. Based on the results, preliminary structure-activity relationships were discussed.