50895-69-7

Upstream product

• 6153-06-6 (E)-3-methylpent-2-en-4-yn-1-ol 
• 14398-40-4 (E)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexenyl)-2-butenal 
• 74-96-4 ethyl bromide 
• 6153-05-5 (Z)-3-methylpent-2-en-4-ynol 
• 3155-71-3 2-methyl-4-(2,6,6-trimethylcyclohex-1-en-1-yl)-2-butenal 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 3230-76-0 2,4,7E-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,7-nonatrien-1,6-diol 
• 29443-88-7 (2E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6,8-trien-4-yn-1-ol 
• 564-88-5 11-cis,13-cis-retinal 
• 17706-49-9 11,13-Di-cis-vitamin A 
• 68-26-8 RETINOL 
• 107892-29-5 O-(9.10-dioxo-9.10-dihydro-anthracenecarbonyl-⁽²⁾)-all-trans-retinol 
• 62417-05-4 (+/-)-9-acetoxy-3.7-dimethyl-1-(2.2.6-trimethyl-cyclohexen-(6)-yl)-nonatrien-(2ξ.5c.7c)-ol-(4) 
• 3230-76-0 (+/-)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2c,4c,7ξ-triene-1,6-diol 
• 3230-76-0 (+/-)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2ξ,4t,7ξ-triene-1,6-diol 
• 25428-56-2 11,12-Didehydro-[7t,9t,13c]retinol 

Relevant academic research and scientific papers

PROCESS OF PRODUCTION OF 3,7-DIMETHYL-9-(2,6,6-TRIMETHYL-1-CYCLOHEXEN-1-YL)-NONA-2E,7E-DIEN-4-YNE-1,6-DIOL

The present invention relates to an improved method for producing 3,7-dimethyl- 9-(2,6,6-trimethyl-1 -cyclohexen-1 -yl)-nona-2E,7E-dien-4-yne-1,6-diol.

Production system and method for continuously preparing alkynol di-Grignard reagent

The invention discloses a production system and method for continuously preparing an alkynol di-Grignard reagent. The production system comprises a material supply device for continuously supplying a mono-Grignard reagent and an alkynol solution, a tower reactor and a phase separation tank. The mono-Grignard reagent and the alkynol solution from the material supply device are continuously input to the feeding segment of the tower reactor, and are premixed in the feeding segment through a distributor; the mono-Grignard reagent and the alkynol solution flow through a reaction segment under the action of gravity and undergo a reaction; and the alkynol di-Grignard reagent is continuously extracted, and a residual solution is recycled. The method and the method realize continuous production of the alkynol di-Grignard reagent; and a reaction solvent and unreacted raw materials of a reaction system are recycled, so the raw material utilization rate is improved, and the quality of the prepared alkynol di-Grignard reagent is improved.

Reduction method for intermediate of vitamin A

The invention relates to a reduction method for an intermediate of vitamin A. The method comprises the following steps: (1) preparing a trans-C6 alcohol di-Grignard reagent, and cooling the trans-C6 alcohol di-Grignard reagent to a certain temperature; (2) dissolving C14 aldehyde into toluene or dichloromethane, dropwise adding the solution into the solution obtained in the step (1), and continuing to carry out a reaction for a certain time while carrying out heat preservation after the dropwise adding is completed; (3) hydrolyzing the reaction solution obtained in the step (2) by an acid, so as to obtain a condensate; (4) mixing the condensate obtained in the step (3) with glacial acetic acid, adding zinc powder into the mixture with intense stirring, holding temperature during reaction, continuing to carry out a reaction while carrying out heat preservation, stopping the reaction when the raw material residual is lower than 2%, carrying out washing by water, and recovering a solvent from an organic layer, so as to obtain a reduction product, i.e., crude oil. According to the method, the vitamin A is synthesized by using waste materials, so that the problem that a Lindlar catalyst is prone to poisoned deactivation in a trans condensate is avoided, the cost is reduced greatly, the production process is simplified, the production of trans-C6 alcohol in a production process is avoided, and the environmental protection is facilitated.