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Upstream product

• 118-92-3 anthranilic acid 
• 148564-70-9 1,4-dimethyl-5-phenyl-2,3-pyrrolinedione 
• 4780-07-8 α-methylhomophthalic anhydride 
• 21737-87-1 N-methyl benzimidoyl chloride 
• 88-67-5 2-Iodobenzoic acid 
• 186249-74-1 (S,E)-N-benzylidene-tert-butylsulfinamide 
• 100-52-7 benzaldehyde 
• 609-67-6 2-Iodobenzoyl chloride 
• 1374162-39-6 (S)-2-methyl-N-((S)-1-phenylallyl)propane-2-sulfinamide 
• 673-32-5 1-Phenylprop-1-yne 
• 88070-48-8 N-methylbenzamide 
• 148564-75-4 N-(α-ethylidenebenzyl)-N-methoxalylmethylamine 
• 93-55-0 1-phenyl-propan-1-one 
• 29640-04-8 N-(α-ethylbenzylidene)methylamine 

Relevant academic research and scientific papers

Electrooxidative Ruthenium-Catalyzed C?H/O?H Annulation by Weak O-Coordination

Electrocatalysis has been identified as a powerful strategy for organometallic catalysis, and yet electrocatalytic C?H activation is restricted to strongly N-coordinating directing groups. The first example of electrocatalytic C?H activation by weak O-coo

Pd/C-catalyzed synthesis of N-aryl and N-alkyl isoquinolones via C[sbnd]H/N[sbnd]H activation

Pd/C-catalyzed direct synthesis of N-aryl and N-alkyl isoquinolones was developed via the annulation reactions of benzamides and alkynes in high yields (up to 99%) through the cleavage of C[sbnd]H/N[sbnd]H bonds. The reaction was ligand-free and air was used as oxidant. High regioselectivities were found when unsymmetrical alkynes or meta-benzamides were used as substrates. The heterocyclic carboxamide substrates, such as furan and thiophene derivatives, also afforded the corresponding products in high yields.

Additive effects in the palladium-catalyzed carboiodination of chiral N-allyl carboxamides

The use of Pd catalysis as a means to synthesize organic halides has recently received increased attention. Among the reported methods is the Pd-catalyzed carboiodination, which uses extremely bulky ligands to facilitate carbon-halogen reductive eliminati

Ruthenium-catalyzed oxidative annulation by cleavage of C-H/N-H bonds

Bond activation in action: Unprecedented ruthenium-catalyzed oxidative annulations of alkynes through cleavage of C-H bonds set the stage for an efficient 1(2H)-isoquinolone synthesis with ample scope (see scheme; tAm=tert-amyl). Mechanistic studies provided strong evidence for a rate-limiting C-H bond metalation through carboxylate assistance. Copyright

Regiochemistry in aryl radical cyclisations (5-exo versus 6-endo) of N-vinylic 2-iodobenzamides

Bu3SnH-mediated aryl radical cyclisations of a range of N-vinylic 2-iodobenzamides 10 were examined. The enamides 10a-d gave exclusively the 5-exo cyclisation products 11a-d, whereas the enamides 10e,f having a phenyl substituent on the vinylic carbon ato

Synthesis of 3-Phenylisoquinolones by Reaction of Simple Pyrroline-2,3-diones with Benzyne. New Mechanistic Considerations

3-Phenylisoquinolones were obtained by cycloaddition of benzyne to 5-phenylpyrroline-2,3-diones.New mechanistic hypotheses for these transformations are discussed.

The Chemistry of Phthalide-3-carboxylic Acid. VI The Stereochemistry of Some 3-Amino(aryl)methylphthalides and the Derived 3-Aryl-4-hydroxy-3,4-dihydroisoquinolin-1(2H)-ones

The isomeric 3-isobenzofuran-1(3H)-ones, of known configuration, have been converted into the corresponding amino and dimethylamino compounds with inversion of configuration, and hence the stereochemistry of these compounds has been

Reactions of Glutaconic and Homophthalic Anhydrides with Imidates, Imidoyl Chlorides, and 1-Chloroisoquinoline

Glutaconic anhydride (9) reacts with N-substituted benzimidoyl chlorides 3 to give the corresponding (Z)-3-pyrandiones 12, whereas with 1-chloroisoquinoline (4) the benzoquinolizinone 13 is obtained.The reactions of α-methylhomophthalic anhydride (10) with 3 and the imidate 7 lead to the 1(2H)-isoquinolinones 14 and 19, respectively, and with 4 to the 13-methyldibenzoquinolizinone 15.The interaction of homophthalic anhydrides 1a, b with 3 aiming at the preparation of α-condensation products is investigated.