51181-40-9

Usage

Uses

Used in Organic Synthesis:
Methyl 4-Methylcyclohexanecarboxylate is used as a starting material for various organic reactions. Its unique structure allows it to be a versatile building block in the synthesis of different organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Methyl 4-Methylcyclohexanecarboxylate is used as an intermediate in the synthesis of various drugs. Its ability to undergo a wide range of chemical reactions makes it a valuable component in the development of new medications.
Used in Agrochemical Industry:
Methyl 4-Methylcyclohexanecarboxylate is also used in the agrochemical industry as a precursor for the synthesis of various agrochemicals, such as insecticides, herbicides, and fungicides. Its reactivity and stability contribute to the development of effective and environmentally friendly products.
Used in Specialty Chemicals:
In the specialty chemicals sector, Methyl 4-Methylcyclohexanecarboxylate is employed as a key component in the production of various specialty chemicals, such as fragrances, dyes, and polymers. Its unique properties enable the creation of innovative and high-performance products.

InChI:InChI=1/C9H16O2/c1-7-3-5-8(6-4-7)9(10)11-2/h7-8H,3-6H2,1-2H3

Upstream product

• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 4331-54-8 4-methylcyclohexanecarboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 99-94-5 p-Toluic acid 
• 78-79-5 isoprene 
• 6493-79-4 methyl 4-methyl-3-cyclohexene-1-carboxylate 
• 67-56-1 methanol 
• 589-91-3 p-methylcyclohexanol 
• 201230-82-2 carbon monoxide 
• 94-60-0 dimethyl 1,4-cyclohexane dicarboxylate 
• 99-75-2 4-methyl-benzoic acid methyl ester 

Downstream Products

• 934-67-8 trans-4-methylcyclohexanecarboxylic acid 
• 934-67-8 (cis)-4-methylcyclohexanecarboxylic acid 
• 41076-10-2 cis-4-methyl-cyclohexane-carboxylic acid-⁽¹⁾-methyl ester 
• 861858-79-9 (cis/trans)-1-(3-tert-butyl-phenyl)-4-methyl-cyclohexanecarboxylic acid methyl ester 
• 1082739-41-0 methyl 1-(4-fluorophenyl)-4-methylcyclohexanecarboxylate 
• 1261562-87-1 1-ethyl-4-methylcyclohexanecarboxylic acid methyl ester 
• 82166-21-0 methyl cyclohexane 
• 589-90-2 1,4 dimethylcyclohexane 
• 4331-54-8 4-methylcyclohexanecarboxylic acid 

Relevant academic research and scientific papers

Towards the Circular Economy: Converting Aromatic Plastic Waste Back to Arenes over a Ru/Nb2O5 Catalyst

The upgrading of plastic waste is one of the grand challenges for the 21st century owing to its disruptive impact on the environment. Here, we show the first example of the upgrading of various aromatic plastic wastes with C?O and/or C?C linkages to arenes (75–85 % yield) via catalytic hydrogenolysis over a Ru/Nb2O5 catalyst. This catalyst not only allows the selective conversion of single-component aromatic plastic, and more importantly, enables the simultaneous conversion of a mixture of aromatic plastic to arenes. The excellent performance is attributed to unique features including: (1) the small sized Ru clusters on Nb2O5, which prevent the adsorption of aromatic ring and its hydrogenation; (2) the strong oxygen affinity of NbOx species for C?O bond activation and Br?nsted acid sites for C?C bond activation. This study offers a catalytic path to integrate aromatic plastic waste back into the supply chain of plastic production under the context of circular economy.

Synthesis of gasoline and jet fuel range cycloalkanes and aromatics from poly(ethylene terephthalate) waste

For the first time, gasoline and jet fuel range C7-C8 cycloalkanes and aromatics were selectively synthesized by the alcoholysis of poly(ethylene terephthalate) (PET) waste, followed by solvent-free hydrogenation and hydrodeoxygenation (HDO). It was found that methanol is highly reactive for the alcoholysis of PET waste. In the absence of any catalyst, a high yield of dimethyl terephthalate (97.3%) was achieved under mild conditions (473 K, 3.5 h). Dimethyl terephthalate exists as a solid and can be automatically separated from methanol with a decrease in temperature. Subsequently, dimethyl terephthalate was liquefied to dimethyl cyclohexane-1,4-dicarboxylate by hydrogenation over noble metal catalysts. Among the investigated catalysts, Pt/C exhibited the highest activity. Finally, the dimethyl cyclohexane-1,4-dicarboxylate as obtained was further hydrodeoxygenated to C7-C8 cycloalkanes and aromatics that can be used as gasoline or additives to improve the densities (or volumetric heat value) and sealabilities of current bio-jet fuels. Bimetallic Ru-Cu/SiO2 was found to be a promising HDO catalyst. According to the characterization results, the excellent HDO performance of Ru-Cu/SiO2 can be explained by the formation of smaller Ru-Cu alloy particles during the catalyst preparation. In real applications, dimethyl cyclohexane-1,4-dicarboxylate can also be simultaneously hydrodeoxygenated with biomass derived oxygenates to produce jet fuel with a suitable content of cycloalkanes and aromatics.

SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

Palladium-Catalyzed Carbonylation of sec- and tert-Alcohols

A general palladium-catalyzed synthesis of linear esters directly from sec- and tert-alcohols is described. Compared to the classic Koch–Haaf reaction, which leads to branched products, this new transformation gives the corresponding linear esters in high yields and selectivity. Key for this protocol is the use of an advanced palladium catalyst system with L2 (pytbpx) as the ligand. A variety of aliphatic and benzylic alcohols can be directly used and the catalyst efficiency for the benchmark reaction is outstanding (turnover number up to 89 000).

Method for producing terephthalic acid

A method for producing terephthalic acid comprises the steps of: subjecting methyl acrylate to contact with aluminum chloride so as to form a complex; adding isoprene to the complex to result in a Diels-Alder reaction which is kept at a temperature no higher than 50° C. by cooling so as to obtain a cyclic adduct product; subjecting the cyclic adduct product to separation so as to obtain a cyclic para-precursor; and subjecting the cyclic para-precursor to a chemical reaction so as to obtain terephthalic acid.

Single-step conversion of dimethyl terephthalate into cyclohexanedimethanol with Ru5PtSn, a trimetallic nanoparticle catalyst

Highly active and selective: A supported Ru5PtSn nanoparticle cluster (the picture shows an axial projection of a tomogram), prepared from the carbonyl cluster [PtRu5(CO)15(μ-SnPh 2)(μ6-C)], is an excellent catalyst in the single-step hydrogenation of dimethyl terephthalate to cyclohexanedimethanol under mild conditions (100°C, 20 bar H2). (Figure Presented).

SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS

The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS

The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INHIBITORS

The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

Single-step, highly active, and highly selective nanoparticle catalysts for the hydrogenation of key organic compounds

Pores for cluster catalysts: Nanoparticles of both Ru5Pt and Ru10Pt2, uniformly distributed along the inner walls of mesoporous silica, exhibit high catalytic performance in the single-step hydrogenation of dimethyl terephthalate (DMT, to 1,4-cyclohexanedimethanol (CHDM); see scheme), of benzoic acid (to cyclohexane carboxylic acid), and of naphthalene (in the presence of sulfur) to cisdecalin.